Detection and Characteristic of Whipple Diseases in the Great Britany

Brief Title

Detection and Characteristic of Whipple Diseases in the Great Britany

Official Title

Detection and Characteristic of Whipple Diseases in the Great Britany

Brief Summary

      Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma
      wipplei on a genetic predisposition which should be considered in patients with recurrent
      episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic
      diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and
      epithelioid granuloma.

      Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive
      protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.

      None of theses findings is specific and most patients have arthritis or low back pain
      mimicking rheumatoid arthritis and spondyloarthritis.

      As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma
      whipplei is low in this context.
    



Study Type

Observational


Primary Outcome

Number of patients diagnosed as whipple's disease

Secondary Outcome

 Number of test performed in each centre

Condition

Whipple Disease


Study Arms / Comparison Groups

 Classic Whipple's disease (CWD)
Description:  Classic Whipple's disease (CWD), defined as
duodenal biopsy positive by PAS/immunohistochemistry
or blood positive by PCR

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

267

Start Date

November 15, 2017

Completion Date

February 9, 2018

Primary Completion Date

February 9, 2018

Eligibility Criteria

        Inclusion Criteria:

          -  Adult

          -  patient with at least a screening test for Whipple'disease

          -  participation agreement,

        Exclusion Criteria:

          -  No test for Whipple'disease
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

France

Location Countries

France

Administrative Informations


NCT ID

NCT03350685

Organization ID

WHO (29BRC17.0179)


Responsible Party

Sponsor

Study Sponsor

University Hospital, Brest


Study Sponsor

, , 


Verification Date

February 2018