Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation

Brief Title

Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation

Official Title

Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation

Brief Summary

      Cytological diagnosis of hepatic angiosarcoma by fine-needle aspiration (FNA) or imprint
      cytology is difficult due not only to its various cytomorphologic features but also clinical
      rarity. Vasoformative features, such as pseudo-acini, branching pseudo-capillary structure,
      and intracytoplasmic lumina, are clues to achieve the diagnosis. But these features are not
      always present. In order to find clues for cytological diagnosis of angiosarcoma, we
      collected cases of hepatic angiosarcoma to study their cytological features. And then
      compared these features with those in their histopathological biopsy or resection.

Detailed Description

      Hepatic angiosarcoma is a rare hepatic malignant tumor. Although diagnosis of hepatic
      angiosarcoma by FNA cytology has been reported since 1982, followed by several studies, its
      cytomorphologic features were still not well recognized by cytopathologists because of its
      clinical rarity and various morphologic features.

      We reviewed literatures about cytomorphology of hepatic angiosarcoma by FNA. There are only
      11 cases retrieved in 10 articles searched from Medline. The sex M/F ratio was 6/4 (one
      unknown); age range was 56 to 79 years old. In initial cytological evaluation, four cases got
      angiosarcoma or consistent/suspicious angiosarcoma diagnosis. Positive for malignancy,
      sarcoma, and poorly differentiated spindle cell lesion were in one case respectively. One was
      diagnosed as atypical cells. Remaining three were unavailable by their reports.

      In cytological morphologic features, all but one met least 2 of 3 cytological cellular
      criteria of angiosarcoma cells: spindle cells, epithelioid cells, and pleomorphic cells. In
      cytological architectural features, 7 of 11 cases showed vasoformative structures; 5 of 11
      cases showed intracytoplasmic lumen or erythrophagocytosis. Ten of 11 cases had
      histologic/pathologic confirmation as angiosarcoma. One case reported interrelation of tumor
      structures and their own accompanied liver tissue in cell blocks.

Study Type


Primary Outcome

all cause mortality


Hepatic Angiosarcoma


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

January 17, 2017

Completion Date

April 3, 2017

Primary Completion Date

February 4, 2017

Eligibility Criteria

        Inclusion criteria:

        Consecutive patients of hepatic angiosarcoma performed FNA and/or imprint cytological
        examinations in our hospital.

        Exclusion criteria:

          1. Patients without pathological confirmation.

          2. Patients who are not angiosarcoma by pathological reviews.




20 Years - 100 Years

Accepts Healthy Volunteers



Wern-Cherng Cheng, MD, , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party


Study Sponsor

National Taiwan University Hospital

Study Sponsor

Wern-Cherng Cheng, MD, Principal Investigator, National Taiwan University Hospital

Verification Date

January 2017