Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients

Brief Title

Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients

Official Title

Integrative Medicine and Tai-chi in Clinical Status of Spinocerebellar Ataxia

Brief Summary

      Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are
      over thirty subtypes, which characterize neurologic features differently. They all have
      obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a
      prevalence of about three cases per 100 000 people is assumed, but this may be an
      underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to
      disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease
      often made patients depressive and hopeless. The recent review of researches concludes no
      effective therapy for the disease. The purpose of the investigator's study is to explore the
      Tai-chi exercise effect for spinocerebellar ataxia.

Study Type


Primary Outcome

Scale for the Assessment and Rating of Ataxia(SARA)


Spinocerebellar Ataxias


Tai chi

Study Arms / Comparison Groups

 Tai chi
Description:  participants in this group accepted Tai chi exercise and conventional medicine.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

May 13, 2013

Completion Date

December 2, 2015

Primary Completion Date

December 2, 2015

Eligibility Criteria

        Inclusion Criteria:

          -  progressive ataxia accompanied with the observation of cerebellar atrophy on magnetic
             resonance or computed tomography images

          -  SARA score of less than 20

        Exclusion Criteria:

          -  Patients with complicated cerebellar disorders, such as multiple system atrophy,
             Parkinson-plus syndromes, secondary cerebellar degeneration from encephalitis, trauma,
             hypoxia, cerebrovascular diseases, and toxic- or drug-induced cerebellar degeneration

          -  SARA score of larger than 20




20 Years - N/A

Accepts Healthy Volunteers



Lun-Chien Lo, , 

Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

Changhua Christian Hospital

Study Sponsor

Lun-Chien Lo, Principal Investigator, Director of Chinese Medicine

Verification Date

February 2022