Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm

Learn more about:
Related Clinical Trial
Data Analysis of Protocol 04-N-0188: Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm Mexiletine for the Treatment of Focal Dystonia A Retrospective Chart Review of BOTOX® and Xeomin® for the Treatment of Cervical Dystonia and Blepharospasm A Retrospective Chart Review of BOTOX® and Xeomin® for the Management of Cervical Dystonia and Blepharospasm An RCT of a Patient-initiated Treatment Service for BEB and HFS Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm Photic Blink Reflex in People With Blepharospasm and Increased Blinking IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm Blepharospasm Short Interval Study of a Single Administration of 3 Doses of Dysport® for the Treatment of Benign Essential Blepharospasm Comparison of Korean Botulinum Toxin Type A Versus Botox in the Treatment of Essential Blepharospasm Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm Brain Changes in Blepharospasm Blepharospasm Patient Survey for Patients With Blepharospasm A Mechanical Device for Blepharospasm Blepharospasm Tools Trial Evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or Blepharospasm in the United States

Brief Title

Comparison of Two Botulinum Type A Products in the Treatment of Blepharospasm

Brief Summary

      This pilot study estimates the treatment effects of two different types of botulinum toxin
      type A in the treatment of Blepharospasm. Blepharospasm is characterised by excessive
      contraction of the muscles around the eye and can lead to repetitive blinking or sustained
      closure of the eyelids.

Study Phase

Phase 4

Study Type


Primary Outcome

Change From Baseline to Week 4 in Blepharospasm Disability Index

Secondary Outcome

 Change From Baseline to Week 8 in Blepharospasm Disability Index




Botulinum Toxin Type A 900kDa

Study Arms / Comparison Groups



* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

July 2006

Completion Date

January 2008

Primary Completion Date

January 2008

Eligibility Criteria

        Inclusion Criteria:

          -  Diagnosed with benign essential blepharospasm

          -  Received ≥20U/eye of BOTOX® for at least one visit prior to study entry and required,
             in the investigators opinion, the same dose at the study injection visit.

          -  Combined Jankovic Rating Score of >2

        Exclusion Criteria:

          -  Female subjects who were pregnant, breastfeeding, or who were of childbirth potential
             and not practicing birth control.

          -  Profound atrophy of the muscles in the target area(s) of injection.

          -  Myasthenia Gravis, Lambert-Eaton Syndrome, Amyotrophic Lateral Sclerosis or any other
             disease that might interfere with neuromuscular function.

          -  Known significantly impaired renal and/or hepatic function




18 Years - N/A

Accepts Healthy Volunteers



Medical Director, , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party


Study Sponsor


Study Sponsor

Medical Director, Study Director, Allergan

Verification Date

October 2013