Classification and Comparison of Early-onset and Late-onset Idiopathic Chronic Pancreatitis

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Brief Title

Classification and Comparison of Early-onset and Late-onset Idiopathic Chronic Pancreatitis

Official Title

Classification and Comparison of Early-onset and Late-onset Idiopathic Chronic Pancreatitis

Brief Summary

      Classification of early-onset idiopathic chronic pancreatitis (EOICP) and late-onset
      idiopathic chronic pancreatitis (LOICP) was proposed based on bimodal distribution of age at
      onset of idiopathic chronic pancreatitis (ICP). However, studies of larger populations prove
      it may be normal distribution. Therefore, the aim of the study is to find what the
      distribution of age at onset of ICP is and whether the classification of EOICP and LOICP is
      meaningful.
    

Detailed Description

      Idiopathic chronic pancreatitis (ICP) patients admitted to the investigator's center from
      January 2000 to December 2013 were enrolled. Characteristics were compared between
      early-onset idiopathic chronic pancreatitis (EOICP) and late-onset idiopathic chronic
      pancreatitis (LOICP) patients. Cumulative rates of diabetes mellitus, steatorrhea, pancreatic
      stone, pancreatic pseudocyst (PPC), biliary stricture, and pancreatic cancer after the onset
      and the diagnosis of ICP were calculated, respectively. Different cut-off values for age at
      onset of ICP were set to classify EOICP and LOICP. Then differences of clinical courses
      between EOICP and LOICP were compared when classified by distinct cut-off values.
    


Study Type

Observational


Primary Outcome

Distribution of age at onset of idiopathic chronic pancreatitis

Secondary Outcome

 Basic characteristics of early-onset idiopathic chronic pancreatitis and late-onset idiopathic chronic pancreatitis with different cut-off values for age at onset of idiopathic chronic pancreatitis

Condition

Chronic Pancreatitis


Study Arms / Comparison Groups

 ICP cohort
Description:  Patients with idiopathic pancreatitis

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1633

Start Date

January 1, 2000

Completion Date

December 31, 2019

Primary Completion Date

December 31, 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Patients diagnosed with idiopathic chronic pancreatitis according to Asia-Pacific
             consensus

        Exclusion Criteria:

          -  Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis

          -  Groove pancreatitis

          -  Autoimmune pancreatitis

          -  Chronic pancreatic patients with identified etiologies
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Zhaoshen Li, Doctor, , 

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT03953937

Organization ID

ICP-1


Responsible Party

Principal Investigator

Study Sponsor

Changhai Hospital


Study Sponsor

Zhaoshen Li, Doctor, Principal Investigator, Changhai Hospital


Verification Date

September 2019