Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)

Brief Title

Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)

Official Title

Brain Perfusion in Pantothenate Kinase-Associated Neurodegeneration (PKAN)

Brief Summary

      The purpose of this study is to learn whether blood flow in the brain is normal in people
      with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data
      suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN,
      may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to
      learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other
      brain regions as well as to healthy controls.
    



Study Type

Observational


Primary Outcome

ASL-derived cerebral blood flow(CBF)


Condition

Pantothenate Kinase-associated Neurodegeneration (PKAN)


Study Arms / Comparison Groups

 PKAN
Description:  This group consists of individuals diagnosed with PKAN using a combination of MRI and PANK2 gene sequencing.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

10

Start Date

April 2013

Completion Date

January 2018

Primary Completion Date

October 2017

Eligibility Criteria

        Inclusion Criteria:

          -  diagnosis of PKAN confirmed by MRI and gene testing

          -  able to undergo MRI for approximately 1 hour without sedation

        Exclusion Criteria:

          -  deep brain stimulators or other conditions that warrant avoidance of a strong magnetic
             field

          -  previous reaction to gadolinium (Gd) contrast agent

          -  acute or chronic kidney dysfunction

          -  pregnant and/or nursing at time of study
      

Gender

All

Ages

7 Years - 75 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Susan J Hayflick, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01838018

Organization ID

8777


Responsible Party

Sponsor-Investigator

Study Sponsor

Susan J. Hayflick

Collaborators

 Oregon Health and Science University

Study Sponsor

Susan J Hayflick, MD, Principal Investigator, Oregon Health and Science University


Verification Date

May 2018