Brief Title
Brain Perfusion in Pantothenate Kinase-associated Neurodegeneration (PKAN)
Official Title
Brain Perfusion in Pantothenate Kinase-Associated Neurodegeneration (PKAN)
Brief Summary
The purpose of this study is to learn whether blood flow in the brain is normal in people
with pantothenate kinase-associated neurodegeneration (PKAN). Specifically, preliminary data
suggest a region of the brain called the globus pallidus (GP), a key region affected by PKAN,
may have reduced blood flow. Standard MRI and perfusion scanning techniques will be used to
learn about cerebral blood flow in the globus pallidus and compare it to blood flow in other
brain regions as well as to healthy controls.
Study Type
Observational
Primary Outcome
ASL-derived cerebral blood flow(CBF)
Condition
Pantothenate Kinase-associated Neurodegeneration (PKAN)
Study Arms / Comparison Groups
PKAN
Description: This group consists of individuals diagnosed with PKAN using a combination of MRI and PANK2 gene sequencing.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
10
Start Date
April 2013
Completion Date
January 2018
Primary Completion Date
October 2017
Eligibility Criteria
Inclusion Criteria:
- diagnosis of PKAN confirmed by MRI and gene testing
- able to undergo MRI for approximately 1 hour without sedation
Exclusion Criteria:
- deep brain stimulators or other conditions that warrant avoidance of a strong magnetic
field
- previous reaction to gadolinium (Gd) contrast agent
- acute or chronic kidney dysfunction
- pregnant and/or nursing at time of study
Gender
All
Ages
7 Years - 75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Susan J Hayflick, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01838018
Organization ID
8777
Responsible Party
Sponsor-Investigator
Study Sponsor
Susan J. Hayflick
Collaborators
Oregon Health and Science University
Study Sponsor
Susan J Hayflick, MD, Principal Investigator, Oregon Health and Science University
Verification Date
May 2018