Brief Title
Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia
Official Title
Observational - WT-1's Role in Leukemogenesis
Brief Summary
This research study is studying biomarkers in patients with acute promyelocytic leukemia.
Studying samples of bone marrow from patients with cancer in the laboratory may help doctors
learn more about changes that occur in DNA and about biomarkers related to cancer.
Detailed Description
OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION:
Samples With DNA BIOSCPECIMEN DESCRIPTION: Bone marrow STUDY POPULATION DESCRIPTION: Primary
Care Clinic SAMPLING METHOD: Non-Probability Sample
PRIMARY OBJECTIVES:
I. To measure WT1 and VEGF-1 expression in patients with acute promyelocytic leukemia.
OUTLINE: This is a multicenter study.
Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and
VEGF-1 expression.
Study Type
Observational
Primary Outcome
WT1 and VEGF-1 expression
Condition
Adult Acute Myeloid Leukemia
Intervention
laboratory biomarker analysis
Study Arms / Comparison Groups
Basic science (correlative studies)
Description: Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
10
Start Date
September 2009
Completion Date
June 2011
Primary Completion Date
June 2011
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of acute promyelocytic leukemia [t(15;17) translocation]
- Not specified
- Not specified
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Mustafa Moazam, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01146223
Organization ID
AAML10B7
Secondary IDs
NCI-2012-02717
Responsible Party
Sponsor
Study Sponsor
Children's Oncology Group
Collaborators
National Cancer Institute (NCI)
Study Sponsor
Mustafa Moazam, MD, Principal Investigator, Children's Oncology Group
Verification Date
May 2015