Austrian Registry on the Outcome of Monochorionic Pregnancies

Brief Title

Austrian Registry on the Outcome of Monochorionic Pregnancies

Official Title

Austrian Registry on the Outcome of Monochorionic Multiple Pregnancies: A Multicenter Registry Study

Brief Summary

      About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third
      of these monozygotic twins share a common placenta and are therefore called monochorionic.
      Due to placental sharing and the ever-present inter-fetal vascular connections, specific
      complications may arise and lead to an increased risk of intrauterine death and long-term
      neurodevelopmental impairment. Specific complications include twin-to-twin transfusion
      syndrome (TTTS), twin-anemia-polycythemia sequence (TAPS), selective intrauterine growth
      restriction (sIUGR) and discordant major anomalies, occurring in about 10%, 5%, 20% and 6% of
      monochorionic diamniotic twins. Prenatal interventions may improve perinatal and long-term
      outcome of affected fetuses. However, general knowledge about early diagnosis of
      monochorionic twins and their specific complications is still limited in a significant number
      of practitioners in Austria and systematic analysis of pregnancy outcomes are not conducted.

      In this prospective multicenter registry study, the investigators aim to include all
      monochorionic pregnancies in Austria. Main outcome parameter is the occurrence of
      complications. Secondary outcomes are gestational age at occurrence of complications,
      gestational age delivery and neonatal outcome. The investigators also strive for long-term
      outcome, especially of infants following complicated pregnancies or preterm birth.
    



Study Type

Observational [Patient Registry]


Primary Outcome

occurrence of specific complications

Secondary Outcome

 gestational age at delivery

Condition

Twin Dichorionic Diamniotic Placenta



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1000

Start Date

May 1, 2017

Completion Date

January 2025

Primary Completion Date

January 2025

Eligibility Criteria

        Inclusion Criteria:

          -  All monochorionic pregnancies diagnosed from 11+0 weeks of gestation

        Exclusion Criteria:

          -  Dichorionic twin pregnancies or higher-grade multiples without a monochorionic pair
      

Gender

Female

Ages

18 Years - 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Philipp Klaritsch, MD, +4331638581641, [email protected]

Location Countries

Austria

Location Countries

Austria

Administrative Informations


NCT ID

NCT03171909

Organization ID

1497/2016


Responsible Party

Sponsor

Study Sponsor

Medical University of Graz

Collaborators

 Medical University of Vienna

Study Sponsor

Philipp Klaritsch, MD, Principal Investigator, Department of Obstetrics and Gynecology, Medical University of Graz, Austria


Verification Date

May 2017