Assessment of Long Acting Penicillin Use in Rheumatic Fever Patients

Brief Title

Prevalence of Rheumatic Heart Disease According to Revised Jones Criteria (2015) in Assiut Governate

Official Title

Prevalence of Rheumatic Heart Disease According to Revised Jones Criteria (2015) in Assiut Governate

Brief Summary

      Prevalence of rheumatic heart disease according to revised jones criteria (2015) in Assiut

Detailed Description

      Although acute rheumatic fever (ARF) has declined in Europe and North America in incidence
      over the past 4 to 6 decades, the disease remains one of the most important causes of
      cardiovascular morbidity and mortality especially in the developing countries that are home
      to the majority of the world's population(1), Incidence rates in these countries still reach
      epidemic levels(2).

      In general, most patients with RHD do not have documented histories of ARF, and they present
      with late complications, such as heart failure, arrhythmia, stroke, endocarditis, or
      pregnancy-related complications(3).

      Echocardiographic screening according to revised jones criteria (2015) (1) is the most
      reliable way of detecting RHD in asymptomatic people, and it can identify large numbers of
      previously undetected cases(4-6).

      People with RHD detected by screening can receive appropriate cardiac care, including
      guideline-recommended secondary prophylaxis(7). This may be a cost-effective approach to
      managing RHD in groups at high risk in Assiut Governate(8). Nevertheless, large scale
      screening has not been undertaken, and studies are underway to determine the best models for
      sustainable targeted screening and to evaluate the impact of screening and treatment on
      clinical outcomes(9).

      In this study, we aimed to determine the role of echocardiographic screening for detecting
      undiagnosed RHD, and to estimate the prevalence of RHD in Assiut Governate.

Study Type


Primary Outcome

The aim of the study is to assess the prevalence of rheumatic heart disease (RHD) according to the American Heart Association modified Jones criteria 2015 (1). Cases will be defined as definite, probable or not RHD.


Rheumatic Fever




* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

June 1, 2021

Completion Date

June 2022

Primary Completion Date

June 2022

Eligibility Criteria

        Inclusion Criteria:

        - Children and young adults aged 5-18 years living in Assiut Governate ,who are attending
        general clinics of Assiut University Children Hospital, were invited to participate in
        echocardiographic screening for RHD in February and October 2021. Informed consent will be
        obtained in writing from participants or their parents after providing explanations of the
        study in local languages.




5 Years - 18 Years


Fahim M. Fahim, 01002798114, [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

Assiut University

Study Sponsor

Fahim M. Fahim, Study Director, Doctor

Verification Date

July 2021