Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome

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Retinopathy of prematurity
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Brief Title

Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome

Official Title

Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome

Brief Summary

      Purpose:Retinopathy of prematurity (ROP) continues tobe a major cause of blindness in
      children. Although ablation of the retina with laser or cryotherapy reduces the incidence of
      blindness by suppressing the neovascular phase of ROP the visual outcomes after treatment are
      often poor. Vascular endothelial growth factor(VEGF) has an important role in the
      pathogenesis of ROP and inhibition of VEGF expression in the neovascular phase might prevent
      destructive neovascularization in ROP. The aim of this study is to determine the safety and
      efficacy of intravitreal bevacizumab in the treatment of retinopathy of prematurity

Study Phase

Phase 2/Phase 3

Study Type

Interventional

Primary Outcome

Clinical appearance

Condition

Retinopathy of Prematurity

Intervention

intravitreal injection

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Start Date

July 2006

Completion Date

November 2006

Eligibility Criteria

        Inclusion Criteria:

          -  Retinopathy of prematurity stages III, IV and V in which we can not treat with laser o
             cryotherAPY

        Exclusion Criteria:

          -  PATIENTS THAT COULD BE TREATED WITH CRYOTHERAPY OR LASER

Gender

All

Ages

1 Month - 12 Months

Accepts Healthy Volunteers

No

Contacts

Maria Martínez-Castellanos, MD, 525510841400, [email protected]

Location Countries

Mexico

Location Countries

Mexico

Administrative Informations

NCT ID

NCT00346814

Organization ID

APEC-001

Study Sponsor

Asociación para Evitar la Ceguera en México

Study Sponsor

Maria Martínez-Castellanos, MD, Principal Investigator, Asociación para Evitar la Ceguera en México

Verification Date

June 2006