A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort

Brief Title

A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort

Official Title

A Study for the Ocular Toxocariasis in the Patients Who Were Diagnosed With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort: TOXOCARA Study

Brief Summary

      TOXOCARA Study is a prospective observational cohort study. The aim of this study is to
      evaluate the incidence of ocular toxocariasis (OT) associated with pulmonary toxocariasis
      (PT) in patients with chest diagnostic image tests (chest X-ray, chest CT) with migrating
      ground glass opacity or nodular lesions. Also a cohort study is to track the results of
      treatment for diagnosed ocular toxocariasis (OT) patients.
    

Detailed Description

      Toxocara canis (also known as dog roundworm) is wide-reaching parasite of dogs and other
      canids. It can spread between animals such as cats, pigs and cows by ingestion of worm eggs
      from the feces of an infected animal.

      In humans, two pathways of infection are known: first, ingestion of the eggs and second,
      larvae encapsulated in the tissues of the infected animal.

      The encapsulated larvae hatch in the small intestine and pass through the barrier to the
      portal vein, the liver, the lung, the eye, etc. and remain as encapsulated larvae or survive
      for a period of time.

      Infection into humans has been reported through ingestion of uncooked liver of cows, pigs,
      sheep, chickens, and meat (muscle).

      When encapsulated larvae migrate to the body such as lungs, eosinophils activate and
      proliferate to eliminate the parasites.

      They can be expressed as ground glass opacity (GGO) or nodular lesion by aggregated
      eosinophils, which are mistaken for lung cancer or pneumonia to be investigated.

      Asthma exacerbation, cough and other symptoms of respiratory system could be revealed, but
      often asymptomatic.

      In this study, the investigators defined pulmonary toxocariasis (PT) as a positive form of
      serum toxocara Ab and migrating pulmonary GGOs or nodular lesions in chest diagnostic image
      tests (chest X-ray, chest CT) from the patient.

      Also ocular toxocariasis (OT) is defined by the clinical manifestation of intraocular
      infection by Toxocara larvae with a positive result of serum toxocara Ab.

      Clinical manifestations of OT may also cause blindness of peripheral granuloma, optic
      neuritis, chorioretinitis, conjunctivitis, keratitis, iridocyclitis and cataract.

      The investigators want to investigate the incidence of OT associated with PT in patients with
      chest diagnostic image tests (chest X-ray, chest CT) with migrating GGOs or nodular lesions.
      Also a cohort study is to track the results of treatment for diagnosed OT patients.
    


Study Type

Observational [Patient Registry]


Primary Outcome

Number of patients with pulmonary toxocariasis (PT)

Secondary Outcome

 Incidence of Cysticercosis

Condition

Toxocariasis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

400

Start Date

July 10, 2017

Completion Date

July 31, 2020

Primary Completion Date

July 31, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Aged 18 years and older

          -  Patient who has positive result of Toxocara Ab

          -  Patient who has history of eating of law animal liver or meat

          -  Patient who has the chest diagnostic image tests (chest X-ray, chest CT) with
             migrating ground glass opacity or nodular lesions.

        Exclusion Criteria:

          -  Age < 18 years

          -  Pregnant woman

          -  Malignant patient

          -  Patient who has pulmonary infectious lesion such as pneumonia, fungus and tuberculosis

          -  Patients who were diagnosed by benign or malignant pulmonary nodule

          -  Patient who was not consented
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Kwang Won Seo, M.D., +82-10-9709-9138, [email protected]

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT03814837

Organization ID

UUH 2017-06-012-001


Responsible Party

Principal Investigator

Study Sponsor

University of Ulsan

Collaborators

 Ulsan University Hospital

Study Sponsor

Kwang Won Seo, M.D., Principal Investigator, Ulsan University Hospital


Verification Date

January 2019