Kyrle disease

Overview

Kyrle disease: A skin disorder often associated with diabetes mellitus or kidney failure.

Symptoms

The list of signs and symptoms mentioned in various sources for Kyrle disease includes the 7 symptoms listed below:

• Papular eruptions
• Hyperkeratotic cone-shaped papular plugs
• Hyperkeratotic verrucous plaques
• Diabetes mellitus
• Hepatic insufficiency
• Presence of albumin in the urine
• Excess sugar in the urine

Note that Kyrle disease symptoms usually refers to various symptoms known to a patient, but the phrase Kyrle disease signs may refer to those signs only noticable by a doctor.

Causes

Other Possible Causes of these Symptoms

• Diabetes mellitus

Diagnosis

In cases of diffuse thickening of the skin, a thyroid profile with T 3 , T 4 , and TSH should be done. This should also identify hypothyroidism. A positive ANA test with a speckled pattern will help identify scleroderma, but a skin biopsy should also be done. An antisclerodermal antibody titer is also useful if available. Esophageal motility studies will be helpful in early diagnosis. A skin biopsy will help identify many of the other conditions mentioned above. Urine for porphyrins will help identify porphyria.