Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Zalcitabine AIDS Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07110 June 28, 1988
Leucovorin calcium For use in combination with 5-fluorouracil for the treatment of metastatic colorectal cancer Glaxo Wellcome Research and Development;5 Moore Drive, PO Box 13398;Research Triangle Park, North Carolina, 27709 June 23, 1988
Dideoxyinosine Acquired immunodeficiency syndrome Bristol-Myers Squibb;2400 West Lloyd Expressway;Evansville, Indiana, 47721 June 22, 1988
Ethinyl Estradiol, USP Turner's syndrome Bio-Technology General Corp.;70 Wood Avenue, South;Iselin, New Jersey, 08830 June 22, 1988
Somatostatin Adjunct to the non-operative management of secreting cutaneous fistulas of the stomach, duodenum, small intestine (jejunum and ileum), or pancreas Ferring Laboratories, Inc.;400 Rella Boulevard, Suite 201;Suffern, New York, 10901 June 20, 1988
Aconiazide Tuberculosis Lincoln Diagnostics;P.O. Box 1128;Decatur, Illinois, 62525 June 20, 1988
Piritrexim isethionate Infections caused by Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium-intracellulare Burroughs Wellcome Company;3030 Cornwallis Road, P.O. Box 12700;Research Triangle Park, North Carolina, 27709 June 13, 1988
Coagulation factor VIIa (recombinant) Hemophilia A Novo Nordisk, Inc.;100 College Road West;Princeton, New Jersey, 08540 June 6, 1988
Superoxide dismutase (recombinant human) Prevention of reperfusion injury to donor organ tissue Bio-Technology General Corp.;70 Wood Avenue, South;Iselin, New Jersey, 08830 May 17, 1988
Interferon alfa-2b (recombinant) Primary malignant brain tumors Schering Corporation;2000 Galloping Hill Road;Kenilworth, New Jersey, 07033 May 13, 1988
Interferon alfa-2a (recombinant) Renal cancer Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07110 April 18, 1988
Praziquantel Neurocysticercosis EM Pharmaceuticals, Inc.;; April 18, 1988
Interferon alfa-2b (recombinant) Invasive carcinoma of the cervix Schering Corporation;2000 Galloping Hill Road;Kenilworth, New Jersey, 07033 April 18, 1988
Trisaccharides A and B Prevention of ABO medical hemolytic reactions arising from ABO-incompatible bone marrow transplantation Chembiomed, Ltd.;P.O. Box 8050, T6H 4NP; April 15, 1988
Tocophersolan oral solution (vitamin E-tpgs) Vitamin E deficiency resulting from malabsorption due to prolonged cholestatic hepatobiliary disease Sterling Winthrop;9 Great Valley Parkway;Malvern, Pennsylvania, 19355 April 15, 1988
Megestrol acetate Patients with anorexia, cachexia, or significant weight loss (=/>10% of baseline body weight) and confirmed diagnosis of AIDS Bristol-Myers Squibb Pharmaceutical Research Institute;2400 West Lloyd Expressway;Evansville, Indiana, 47721 April 13, 1988
Monoclonal antibody 17-1a Pancreatic cancer Centocor, Inc.;244 Great Valley Parkway;Malvern, Pennsylvania, 19355 April 4, 1988
Heme arginate Symptomatic stage of acute porphyria Orphan Europe SARL;Immeuble Le Wilson, 70 avenue du General de Gaulle;92800 Puteaux March 10, 1988
Propamidine isethionate 0.1% ophthalmic solution Acanthamoeba keratitis Bausch & Lomb;Pharmaceuticals Division, 8500 Hidden River Parkway;Tampa, Florida, 33637 March 10, 1988
Levocabastine HCl ophthalmic suspension 0.05% Vernal keratoconjunctivitis Iolab Pharmaceuticals;500 Iolab Drive;Claremont, California, 94608 February 29, 1988
Anagrelide Essential thrombocythemia Roberts Pharmaceutical Corp.;Meridian Center III, 6 Industrial Way West;Eatontown, New Jersey, 07724 January 27, 1988
Ceramide trihexosidase/alpha-galactosidase A Fabry disease Genzyme Corporation;One Kendall Square;Cambridge, Massachusetts, 02139 January 19, 1988
Trimetrexate glucuronate Patients with advanced non-small cell carcinoma of the lung Medimmune Oncology, Inc.;One MedImmune Way;Gaithersburg, Maryland, 20878 January 13, 1988
Pentamidine isethionate Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease Fujisawa USA, Inc.;3 Parkway North Center;Deerfield, Illinois, 60015 January 12, 1988
Mesna Inhibition of the urotoxic effects induced by oxazaphosphorine compounds such as cyclophosphamide Asta Medica , Inc.;890 East St.;Tewksbury, Massachusetts, 01876 December 16, 1987