Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Sargramostim Neutropenia associated with bone marrow transplant, for the treatment of graft failure and delay of engraftment, and for the promotion of early engraftment Immunex Corporation;51 University Street;Seattle, WA, 98101 May 3, 1990
Interferon alfa-2a (recombinant) For the concomitant administration with Teceleukin for the treatment of metastatic renal cell carcinoma Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07119 May 2, 1990
Anti-cytomegalovirus monoclonal antibodies 1. human cytomegalovirus infection in bone marrow and organ transplant patients 2. Prevention of human cytomegalovirus infection in bone marrow and organ transplant patients Biomedical Research Institute;345 North Smith Avenue;St. Paul, Minnesota, 55102 May 2, 1990
Anti-cytomegalovirus monoclonal antibodies Prevention of human cytomegalovirus infection in bone marrow and organ transplant patients Biomedical Research Institute;345 North Smith Avenue;St. Paul, MN, 55102 May 2, 1990
Anti-cytomegalovirus monoclonal antibodies Human cytomegalovirus infection in bone marrow and organ transplant patients Biomedical Research Institute;345 North Smith Avenue;St. Paul, MN, 55102 May 2, 1990
Chelmab-y or chelamusab-Y Ovarian cancer Cytogen Corporation;600 College Road East;Princeton, New Jersey, 08540 April 24, 1990
Fluorouracil For use in combination with interferon alpha-2a, recombinant, for the treatment of advanced colorectal carcinoma Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07110 April 18, 1990
N-acetylprocainamide To lower the defibrillation energy requirement sufficiently to allow automatic implantable cardioverter defibrillator therapy in those patients who could otherwise not use the device Medco Research, Inc.;8455 Beverly Blvd., Suite 308;Los Angeles, California, 90048 March 23, 1990
Monoclonal antibodies PM-81 and AML-2-23 For the exogenous depletion of CD14 and CD15 positive acute myeloid leukemic bone marrow cells from patients undergoing bone marrow transplantation Medarex, Inc.;519 Route 173 West;Bloomsbury, New Jersey, 08804 March 12, 1990
Sucralfate suspension Oral complications of chemotherapy in bone marrow transplant patients Darby Pharmaceuticals, Inc.;100 Banks Avenue;Rockville Centre, New York, 11570 March 12, 1990
Thalidomide Graft Versus Host Disease Andrulis Research Corporation;11800 Baltimore Avenue, Suite 113;Beltsville, Maryland, 20705 March 5, 1990
Disodium clodronate tetrahydrate Increased bone resorption due to malignancy Anthra Pharmaceuticals, Inc.;103 Carnegie Center, Suite 102;Princeton, New Jersey, 08540 March 5, 1990
Thalidomide Graft Versus Host Disease Andrulis Research Corporation;11800 Baltimore Avenue, Suite 113;Beltsville, Maryland, 20705 March 5, 1990
Dextran 70 Recurrent corneal erosion unresponsive to conventional therapy Holles Laboratories, Inc.;30 Forest Notch;Cohasset, Massachusetts, 02025 March 5, 1990
Disaccharide tripeptide glycerol dipalmitoyl Pulmonary and hepatic metastases in patients with colorectal adenocarcinoma ImmunoTherapeutics, Inc.;3505 Riverview Circle;Moorhead, Minnesota, 56560 March 1, 1990
Poloxamer 188 Severe burns requiring hospitalization CytRx Corporation;154 Technology Parkway;Norcross, Georgia, 30092 February 22, 1990
Glyceol To decrease intracranial hypertension and/or alleviate cerebral edema in patients who may benefit from osmotherapy Chugai Pharmaceutical Co., Ltd.;; February 22, 1990
Sermorelin acetate Adjunct to gonadotropin therapy in the induction of ovulation in women with anovulatory or oligo-ovulatory infertility who fail to ovulate in response to adequate treatment with clomiphene citrate alone and gonadotropin therapy alone EMD Serono, Inc.;One Technology Place;Rockland, Massachusetts, 02370 February 13, 1990
Interleukin-2 Metastatic malignant melanoma Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07119 February 6, 1990
Indium In-111 altumomab pentetate Detection of suspected and previously unidentified tumor foci of recurrent colorectal carcinoma Hybritech, Inc.;11095 Torreyanna Road;San Diego, California, 92196 February 6, 1990
Dynamine Lambert-Eaton Myasthenic Syndrome Mayo Foundation;200 First Street Southwest;Rochester, Minnesota, 55905 February 5, 1990
Interleukin-2 Metastatic renal cell carcinoma Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07110 February 5, 1990
Ricin (blocked) conjugated murine MCA (anti-my9) For use in the ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia ImmunoGen, Inc.;830 Winter Street;Waltham, Massachusetts, 02451 February 1, 1990
PEG-interleukin-2 Primary immunodeficiencies associated with T-cell defects Chiron Corporation;4560 Horton Street;Emeryville, California, 94608 February 1, 1990
Melanoma vaccine Stage III - IV melanoma Ribi ImmunoChem Research, Inc.;533 Old Corvallis Road;Hamilton, Montana, 59840 December 20, 1989