• A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
• A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
• A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling
• A novel zeta-associated protein 70 homozygous mutation causing combined immunodeficiency presenting as neonatal autoimmune hemolytic anemia
• A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling
• A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45
• A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex
• A rare disease: ZAP70 deficiency
• Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
• An infant with ZAP-70 deficiency with disseminated mycobacterial disease
• Application of PD-1 Blockade in Cancer Immunotherapy
• Autologous Dendritic Cells in Combination With Chemotherapy Restore Responsiveness of T Cells in Breast Cancer Patients: A Single-Arm Phase I/II Trial
• BAP31 affects macrophage polarization through regulating helper T cells activation
• Cbl-b deficiency prevents functional but not phenotypic T cell anergy
• CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection
• Clinical and Mutation Description of the First Iranian Cohort of Infantile Inflammatory Bowel Disease: The Iranian Primary Immunodeficiency Registry (IPIDR)
• Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review
• Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India
• Clinical, Immunological, and Molecular Findings in 57 Patients With Severe Combined Immunodeficiency (SCID) From India
• Comparison of [³H]-Thymidine, Carboxyfluorescein Diacetate Succinimidyl Ester and Ki-67 in Lymphocyte Proliferation
• Correction of T cell deficiency in ZAP-70 knock-out mice by simple intraperitoneal adoptive transfer of thymocytes
• Critical role of the CD44^lowCD62L^low CD8⁺ T cell subset in restoring antitumor immunity in aged mice
• Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells
• CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation
• Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells
• Differential diagnosis of primary immunodeficiency in patients with BCGitis and BCGosis: A single-centre study
• Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
• Dysregulation of Epstein-Barr Virus Infection in Hypomorphic ZAP70 Mutation
• Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity
• Emergency treatment for zeta chain-associated protein of 70 kDa (ZAP70) deficiency
• EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children
• gammadelta CD8+ T cells and novel genetic variants in ZAP70 deficiency
• Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells
• Genetically encoded Runx3 and CD4⁺ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy
• HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4⁺ T Cell Activation and Th17 Cell Differentiation
• Identification of LAT/ZAP70 characterized immune subtypes of prostate cancer
• Immunodeficiency
• Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation
• Inefficient CAR-proximal signaling blunts antigen sensitivity
• Inherited lymphoproliferative disorders
• Inhibition of T cell activation and function by the adaptor protein CIN85
• Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 70 kDa' inhibitors: a review
• Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells
• Intrathymic progenitor cell transplantation across histocompatibility barriers results in the persistence of early thymic progenitors and T-cell differentiation
• K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation
• Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway
• Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome
• Long-Term Outcomes of Hematopoietic Stem Cell Transplantation for ZAP70 Deficiency
• Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
• Low T cell receptor excision circles (TRECs) in a case of ZAP 70 deficient severe combined immunodeficiency (SCID) with a novel mutation from India
• LPL deletion is associated with poorer response to ibrutinib-based treatments and overall survival in TP53-deleted chronic lymphocytic leukemia
• Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors
• Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice
• Mitochondrial Glycerol-3-Phosphate Acyltransferase-Dependent Phospholipid Synthesis Modulates Phospholipid Mass and IL-2 Production in Jurkat T Cells
• Modulation of Orai1 and STIM1 by Cellular Factors
• Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry
• NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling
• Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
• Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in <em>ZAP70</em> and <em>RNF168</em>
• Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder
• Novel Mutation of ZAP-70-related Combined Immunodeficiency: First Case from the National Iranian Registry and Review of the Literature
• Novel ZAP-70-Related Immunodeficiency Presenting with Epstein-Barr Virus Lymphoproliferative Disorder and Hemophagocytic Lymphohistiocytosis
• Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
• Plasma membrane sphingomyelin modulates thymocyte development by inhibiting TCR-induced apoptosis
• Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia
• PSGL-1 attenuates early TCR signaling to suppress CD8⁺ T cell progenitor differentiation and elicit terminal CD8⁺ T cell exhaustion
• Rare Biallelic Variants Affecting the Interdomain B Region of Zeta-Chain Associated Protein Kinase 70 (ZAP70) Protein in a Sudanese Patient: Case Report
• Reactive Oxygen Species Regulate Innate But Not Adaptive Inflammation in ZAP70-Mutated SKG Arthritic Mice
• Redox sensor NPGPx restrains ZAP70 activity and modulates T cell homeostasis
• Retinoic Acid Modulates Hyperactive T Cell Responses and Protects Vitamin A-Deficient Mice against Persistent Lymphocytic Choriomeningitis Virus Infection
• Retrospective TREC testing of newborns with Severe Combined Immunodeficiency and other primary immunodeficiency diseases
• RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells
• SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex
• Silent brain infarcts in two patients with zeta chain-associated protein 70 kDa (ZAP70) deficiency
• Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells
• Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
• Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation
• SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling
• T Cell Immune Deficiency in <em>zap70</em> Mutant Zebrafish
• T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells
• T-cell activation RhoGTPase-activating protein plays an important role in T_H17-cell differentiation
• The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling
• The posttraumatic response of CD4+ regulatory T cells is modulated by direct cell-cell contact via CD40L- and P-selectin-dependent pathways
• The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
• The sufficiency of genetic diagnosis in managing patients with inborn errors of immunity during prenatal care and childbearing
• Time-dependent decline of T-cell receptor excision circle levels in ZAP-70 deficiency
• TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity
• TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection
• Two novel mutations in ZAP70 gene that result in human immunodeficiency
• Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype
• Very Elevated IgE, Atopy, and Severe Infection: A Genomics-Based Diagnostic Approach to a Spectrum of Diseases
• ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia
• ZAP-70 in Signaling, Biology, and Disease
• ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis
• ZAP70 deficiency promotes reverse cholesterol transport through MAPK/ERK pathway in Jurkat cell
• Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse
• zeta Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance
• γδ CD8+ T cells and novel genetic variants in ZAP70 deficiency
• γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program
• ζ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance