Disease: Triose phosphate-isomerase deficiency
- A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency
- A metabolic bypass of the triosephosphate isomerase reaction
- A redesigned Escherichia coli triosephosphate isomerase restores growth properties in a bacterial strain useful for Immobilized Metal Affinity Chromatography (IMAC)
- Alterations of the glucose metabolism in a triose phosphate isomerase-negative Saccharomyces cerevisiae mutant
- Analysis of glycolytic enzyme co-localization in Drosophila flight muscle
- Antibiotic-free segregational plasmid stabilization in Escherichia coli owing to the knockout of triosephosphate isomerase (tpiA)
- Arsenic resistance in Pteris vittata L.: identification of a cytosolic triosephosphate isomerase based on cDNA expression cloning in Escherichia coli
- Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency
- Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency
- Child Neurology: Triosephosphate isomerase deficiency
- Chronic axonal neuropathy with triosephosphate isomerase deficiency
- Comparison of several enzymes between normal physeal and tibial dyschondroplastic cartilage of broiler chickens
- Defects in leaf carbohydrate metabolism compromise acclimation to high light and lead to a high chlorophyll fluorescence phenotype in Arabidopsis thaliana
- Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology
- Determination of the amino acid requirements for a protein hinge in triosephosphate isomerase
- Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline
- Different contribution of conserved amino acids to the global properties of triosephosphate isomerases
- Differential effects on enzyme stability and kinetic parameters of mutants related to human triosephosphate isomerase deficiency
- Diminished blood levels of reduced glutathione and alpha-tocopherol in two triosephosphate isomerase-deficient brothers
- Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae
- Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency
- Drosophila model of human inherited triosephosphate isomerase deficiency glycolytic enzymopathy
- Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency
- Effects of the loss of triose phosphate isomerase activity on carbon metabolism in Kluyveromyces lactis
- Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction
- Enhanced association of mutant triosephosphate isomerase to red cell membranes and to brain microtubules
- Enhanced production of 1,2-propanediol by tpi1 deletion in Saccharomyces cerevisiae
- Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency
- Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity
- First genetic classification of Cryptosporidium and Giardia from HIV/AIDS patients in Malaysia
- Generation and analysis of TPI deficiency zebrafish model
- Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis
- Genetic variation at three enzyme loci within a Thailand population of Opisthorchis viverrini
- Glycolytic enzyme defects and neurodegeneration
- Hemolytic anemia and progressive neurologic impairment: think about triosephosphate isomerase deficiency
- Hsp70- and Hsp90-mediated proteasomal degradation underlies TPI sugarkill pathogenesis in Drosophila
- Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7
- Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes
- Identification of protein quality control regulators using a Drosophila model of TPI deficiency
- Impact of temporal changes and host factors on the genetic structure of a population of Opisthorchis viverrini sensu lato in Khon Kaen Province (Thailand)
- In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: Towards a predictive framework for TPI deficiency
- Increased erythrocyte deformability in fetal erythropoiesis and in erythrocytes deficient in glucose-6-phosphate dehydrogenase and other glycolytic enzymes
- Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency
- Isolation, nucleotide sequence, and physiological relevance of the gene encoding triose phosphate isomerase from Kluyveromyces lactis
- Itavastatin and resveratrol increase triosephosphate isomerase protein in a newly identified variant of TPI deficiency
- Ketogenic and anaplerotic dietary modifications ameliorate seizure activity in Drosophila models of mitochondrial encephalomyopathy and glycolytic enzymopathy
- Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency
- Medical and Veterinary Importance of the Moonlighting Functions of Triosephosphate Isomerase
- Metabolic correction of triose phosphate isomerase deficiency in vitro by complementation
- Metabolic pathway analysis of enzyme-deficient human red blood cells
- Mild hemolytic anemia, progressive neuromotor retardation and fatal outcome: a disorder of glycolysis, triose- phosphate isomerase deficiency
- Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo
- Neuromuscular dysfunction and pathogenesis in triosephosphate isomerase deficiency
- New haplotype for the Glu104Asp mutation in triose-phosphate isomerase deficiency and prenatal diagnosis in a Spanish family
- New procedures to measure synthase and phosphatase activities of bisphosphoglycerate mutase. Interest for development of therapeutic drugs
- Newly discovered roles of triosephosphate isomerase including functions within the nucleus
- Novel human pathological mutations. Gene symbol: TPI1. Disease: triosephosphate isomerase deficiency
- Reappraisal of triosephosphate isomerase deficiency
- Red cell glycolytic enzyme disorders caused by mutations: an update
- Regulation of triosephosphate isomerase (TPI) gene expression in TPI deficient lymphoblastoid cells
- Restoring a metabolic pathway
- Reversal of metabolic block in glycolysis by enzyme replacement in triosephosphate isomerase-deficient cells
- Search for the pathogenesis of the differing phenotype in two compound heterozygote Hungarian brothers with the same genotypic triosephosphate isomerase deficiency
- Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans
- Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding
- Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics
- Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface
- The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
- The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme
- The essential role of plastidial triose phosphate isomerase in the integration of seed reserve mobilization and seedling establishment
- The feasibility of replacement therapy for inherited disorder of glycolysis: triosephosphate isomerase deficiency (review)
- The importance of hinge sequence for loop function and catalytic activity in the reaction catalyzed by triosephosphate isomerase
- The mechanism by which TATA-box polymorphisms associated with human hereditary diseases influence interactions with the TATA-binding protein
- The molecular basis of disorders of red cell enzymes
- The relationship of the -5, -8, and -24 variant alleles in African Americans to triosephosphate isomerase (TPI) enzyme activity and to TPI deficiency
- The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions
- Thiol stress-dependent aggregation of the glycolytic enzyme triose phosphate isomerase in yeast and human cells
- Three consecutive cytosolic glycolysis enzymes modulate autophagic flux
- Towards enzyme-replacement treatment in triosephosphate isomerase deficiency
- Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene
- Triose phosphate isomerase deficiency in 3 French families: two novel null alleles, a frameshift mutation (TPI Alfortville) and an alteration in the initiation codon (TPI Paris)
- Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes
- Triose phosphate isomerase deficiency: a rare erythrocyte enzymopathy with a poor prognosis
- Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in <em>Drosophila melanogaster</em>
- Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster
- Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition
- Triosephosphate isomerase deficiency in a child with congenital hemolytic anemia and severe hypotonia
- Triosephosphate isomerase deficiency with elevated sweat chloride test: report of a case
- Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease
- Triosephosphate isomerase deficiency: a patient with Val231Met mutation
- Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels
- Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure
- Triosephosphate isomerase deficiency: facts and doubts
- Triosephosphate isomerase deficiency: historical perspectives and molecular aspects
- Triosephosphate isomerase deficiency: new insights into an enigmatic disease
- Triosephosphate isomerase deficiency: predictions and facts
- Triosephosphate isomerase deficiency. genetic, enzymatic and metabolic characterization of a new case from Spain
- Triosephosphate isomerase gene promoter variation: -5G/A and -8G/A polymorphisms in clinical malaria groups in two African populations
- Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency
- wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death