Disease: Thyroid hormone plasma membrane transport defect
- A Historical Reflection on Scientific Advances in Understanding Thyroid Hormone Action
- A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing
- A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508
- A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis
- A spontaneously arising mutation in connexin32 with repeated passage of FRTL-5 cells coincides with increased growth rate and reduced thyroxine release
- ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms
- Activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger in isolated cardiomyocytes through β-Raf dependent pathways. Role of Thr<sup>653</sup> of the cytosolic tail
- Adeno Associated Virus 9-Based Gene Therapy Delivers a Functional Monocarboxylate Transporter 8, Improving Thyroid Hormone Availability to the Brain of Mct8-Deficient Mice
- Analysis of the T354P mutation of the sodium/iodide cotransporter gene in children with congenital hypothyroidism due to dyshormonogenesis
- Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS)
- Case of Resistance to Thyroid Hormones With a Relatively Rare Mutation in Thyroid Hormones Receptor
- Chapter 2 Thyroid Hormone Synthesis And Secretion
- Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis
- Clinical case seminar in pediatric thyroid disease
- Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells
- Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07
- Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas
- Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants
- Determining the Crystal Structure of TRPV6
- Different causes of reduced sensitivity to thyroid hormone: diagnosis and clinical management
- Dopamine modulates metabolic rate and temperature sensitivity in Drosophila melanogaster
- Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice
- Effect of excess iodine intake on thyroid on human health
- Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects
- Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats
- Efficient Activation of Pathogenic deltaPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones
- Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones
- Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol-3-phosphate dehydrogenase gene
- Fgf2 and Ptpn11 play a role in cerebral injury caused by sevoflurane anesthesia
- Follow the ATP: tumor energy production: a perspective
- Genetic disorders of thyroid development, hormone biosynthesis and signalling
- Genetics and phenomics of Pendred syndrome
- Genetics of primary congenital hypothyroidism-a review
- Histidine residue at position 226 is critical for iodide uptake activity of human sodium/iodide symporter
- hNIS protein in thyroid: the iodine supply influences its expression and localization
- Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2
- Impaired sensitivity to thyroid hormone
- Impaired Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and Action
- Implications of Na(+)/I(-) Symporter Transport to the Plasma Membrane for Thyroid Hormonogenesis and Radioiodide Therapy
- Implications of Na<sup>+</sup>/I<sup>-</sup> Symporter Transport to the Plasma Membrane for Thyroid Hormonogenesis and Radioiodide Therapy
- Implications of the molecular characterization of the sodium-iodide symporter (NIS)
- Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine
- Inherited defects in thyroid hormone cell-membrane transport and metabolism
- Inherited defects of thyroid hormone-cell-membrane transport: review of recent findings
- Inherited Disorders of Thyroid Hormone Metabolism Defect Caused by the Dysregulation of Selenoprotein Expression
- Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland
- Iodine, sodium-iodine symporter and thyroid diseases
- Lack of correlation for sodium iodide symporter mRNA and protein expression and analysis of sodium iodide symporter promoter methylation in benign cold thyroid nodules
- MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase
- Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency
- Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)
- Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8
- Mechanisms of thyroid hormone action
- Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid
- Minireview: thyroid hormone transporters: the knowns and the unknowns
- Misfolded G Protein-Coupled Receptors and Endocrine Disease. Molecular Mechanisms and Therapeutic Prospects
- Molecular aspects of thyroid hormone actions
- Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy
- Monocarboxylate transporter 8 in neuronal cell growth
- Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C
- Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution
- Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating
- Neonatal STZ model of type II diabetes mellitus in the Fischer 344 rat: characteristics and assessment of the status of the hepatic adrenergic receptors
- Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
- Novel Sodium/Iodide Symporter Compound Heterozygous Pathogenic Variants Causing Dyshormonogenic Congenital Hypothyroidism
- Phylogenetic analysis of the human thyroglobulin regions
- Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration
- Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by <em>MCT8</em> Gene Mutation
- Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by MCT8 Gene Mutation
- Prevention of abnormal sarcoplasmic reticulum calcium transport and protein expression in post-infarction heart failure using 3, 5-diiodothyropropionic acid (DITPA)
- Sodium/Iodide Symporter Mutant V270E Causes Stunted Growth but No Cognitive Deficiency
- Sorting Variants of Unknown Significance Identified by Whole Exome Sequencing: Genetic and Laboratory Investigations of Two Novel <em>MCT8</em> Variants
- Subcellular remodeling and heart dysfunction in chronic diabetes
- Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination
- The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9
- The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome
- The iodide-transport-defect-causing mutation R124H: a delta-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter
- The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter
- The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland
- The Protein Translocation Defect of MCT8(L291R) Is Rescued by Sodium Phenylbutyrate
- The Protein Translocation Defect of MCT8<sup>L291R</sup> Is Rescued by Sodium Phenylbutyrate
- The Role of Maternal Thyroid Hormones in Avian Embryonic Development
- The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance
- The syndromes of reduced sensitivity to thyroid hormone
- The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis
- Therapeutic applications of thyroid hormone analogues
- Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes
- Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas
- Thyroid hormone action in chronic kidney disease
- Thyroid hormone cell membrane transport defect
- Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney
- Thyroid Hormone Hyposensitivity: From Genotype to Phenotype and Back
- Thyroid hormone is required for pruning, functioning and long-term maintenance of afferent inner hair cell synapses
- Thyroid hormone transport in and out of cells
- Thyroid hormone transporters and resistance
- Thyroid hormones and fetal neurological development
- Thyroid stimulating hormone directly modulates cardiac electrical activity
- Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
- TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells
- Understanding the hypothalamus-pituitary-thyroid axis in mct8 deficiency