Disease: Pyruvate kinase deficiency- muscle type
- 31P NMR studies of creatine kinase flux in M-creatine kinase-deficient mouse heart
- 5'-AMP activated protein kinase α2 controls substrate metabolism during post-exercise recovery via regulation of pyruvate dehydrogenase kinase 4
- A high-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca<sup>2+</sup> homeostasis dysfunction
- A mitochondrial encephalomyopathy due to partial cytochrome c oxidase deficiency with giant evoked potentials--a case report
- Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation
- Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis
- Adenosine monophosphate-activated protein kinase is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice
- Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism
- Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish
- AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth
- Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines
- AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues
- Biochemical and morphological studies of skeletal muscle in experimental chronic alcoholic myopathy
- Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress
- Causal mechanisms of multiple acquired red cell enzyme defects in a patient with acquired dyserythropoiesis
- Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts
- Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice
- Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion
- Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α
- Electrophoretic, immunologic and kinetic characterization of erythrocyte pyruvate kinase in the Basenji dog with pyruvate kinase deficiency
- Endothelial nitric oxide synthase (NOS) deficiency affects energy metabolism pattern in murine oxidative skeletal muscle
- Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism
- Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
- Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
- FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity
- Glucose uptake, glucose transporter GLUT4, and glycolytic enzymes in brown adipose tissue from rats adapted to a high-protein diet
- Glucose-free/high-protein diet improves hepatomegaly and exercise intolerance in glycogen storage disease type III mice
- Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
- Identification of pyruvate kinase variants from red blood cells using trypsinization and electrophoresis
- IFN-γ inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice
- Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes
- Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes
- Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis
- JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes
- Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise
- Lack of dystrophin is associated with altered integration of the mitochondria and ATPases in slow-twitch muscle cells of MDX mice
- Lactate dehydrogenase M-subunit deficiency: a new type of hereditary exertional myopathy
- Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction
- Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress
- Mechanisms of the acquired erythrocyte enzyme deficiencies in blood diseases
- Metabolic basis of improved exercise tolerance: muscle phosphorylase deficiency after glucagon administration
- Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells
- Mitochondrial dysfunction and consequences in calpain-3-deficient muscle
- Multiple genotypes, multiple phenotypes, and partial defects
- Muscle creatine kinase-deficient mice. I. Alterations in myofibrillar function
- Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis
- Myoglobinuria and skeletal muscle phosphorylase deficiency: report of a case of McArdle's disease
- Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
- Novel role of the ER/SR Ca<sup>2+</sup> sensor STIM1 in the regulation of cardiac metabolism
- Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis
- PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation
- PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
- Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis
- PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke
- Postnatal hematologic development in phosphofructokinase-deficient dogs
- PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
- Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet
- Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice
- Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation
- Red blood cell PK deficiency: An update of PK-LR gene mutation database
- Reprogramming of aerobic glycolysis in non-transformed mouse liver with pyruvate dehydrogenase complex deficiency
- Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction
- Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy
- Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
- Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice
- The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
- Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice
- Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice
- Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts
- Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha)