Disease: Protein R deficiency
- A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID
- A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration
- A Novel Nanozyme to Enhance Radiotherapy Effects by Lactic Acid Scavenging, ROS Generation, and Hypoxia Mitigation
- A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency
- Aberrant Lipid Accumulation leads to Retinal Pigmental Epithelium Dysfunction and Photoreceptor Degeneration in Prcd -deficient mice
- ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1
- Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
- ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion
- Amyloid precursor protein induces reactive astrogliosis
- Angiotensin receptors and alpha(1B)-adrenergic receptors regulate native IK((ACh)) and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms
- Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R
- Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
- APX2 Is an Ascorbate Peroxidase-Related Protein that Regulates the Levels of Plastocyanin in Chlamydomonas
- AZGP1 deficiency promotes angiogenesis in prostate cancer
- Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion
- BAP1 Loss, Nuclear Grading, and Nonepithelioid Features in the Diagnosis of Mesothelioma in Italy: Nevermore without the Pathology Report
- BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
- Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
- BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes
- BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL
- Caspase-1 Deficiency Modulates Adipogenesis through Atg7-Mediated Autophagy: An Inflammatory-Independent Mechanism
- CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-kappaB/NLRP3 signaling in a breast cancer mouse model
- CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice
- Cholinergic neurotransmission controls orexigenic endocannabinoid signaling in the gut in diet-induced obesity
- Circular RNA circEfnb2 promotes cell injury after cerebral infarction by sponging miR-202-5p and regulating TRAF3 expression
- Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
- Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder
- Clinical and molecular significance of flow cytometric analysis for reactive oxygen species production and residual p67(phox) expression in p67(phox)-deficient chronic granulomatous disease
- Clinical Characteristics, Developmental Trajectory, and Caregiver Burden of Patients With Creatine Transporter Deficiency (SLC6A8)
- CRISPR RNA-Guided Transposases Facilitate Dispensable Gene Study in Phage
- Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes
- Deficiency of Cbfbeta in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFbeta, and Wnt/beta-catenin signaling pathways
- Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
- DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells
- Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
- DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair
- E93 is indispensable for reproduction in ametabolous and hemimetabolous insects
- EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Upregulation of CD47
- Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
- Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
- EspP2 Regulates the Adhesion of <em>Glaesserella parasuis</em> via Rap1 Signaling Pathway
- Expression and processing of mature human frataxin after gene therapy in mice
- Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease
- First-line combination treatment with PARP and androgen receptor-signaling inhibitors in HRR-deficient mCRPC: Applying clinical study findings to clinical practice in the United States
- Folate receptor alpha protein expression in ovarian serous cystadenocarcinoma tumors of The Cancer Genome Atlas: exploration beyond single-agent therapy
- Genetic Determined Iron Starvation Signature in Friedreich's Ataxia
- Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
- Growth performance and nitrogen excretion of broiler chickens fed low protein diets supplemented with crystalline amino acids
- Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency
- Identifying high-risk neurological phenotypes in adult-onset classic monogenic autoinflammatory diseases: when should neurologists consider testing?
- Infectious complications in pediatric patients undergoing CD19+CD22+ chimeric antigen receptor T-cell therapy for relapsed/refractory B-lymphoblastic leukemia
- Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
- Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation
- Intranasal oxytocin suppresses seizure-like behaviors in a mouse model of NGLY1 deficiency
- Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
- Mathematical model calibrated to <em>in vitro</em> data predicts mechanisms of antiviral action of the influenza defective interfering particle "OP7"
- MATRIN3 deficiency triggers autoinflammation via cGAS-STING activation
- Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists
- MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension
- Minimizing higher-order aggregation maximizes iron mobilization by small molecules
- Molecular and cellular consequences of mevalonate kinase deficiency
- Molecular Mechanisms of Iron Transport and Homeostasis Regulated by Antarctic Krill-Derived Heptapeptide-Iron Complex
- Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity of Multivalent Meningococcal Polysaccharide Conjugate Vaccines
- Navigating the Diagnostic Journey in Pediatric Gastroenterology: Decoding Recurrent Vomiting and Epigastric Pain in a Child with Glutaric Aciduria Type II
- NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer
- NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
- OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation
- Potential Complementary Effect of Zinc and <em>Alkalihalobacillus clausii</em> on Gut Health and Immunity: A Narrative Review
- Primordial germ cell DNA demethylation and development require DNA translesion synthesis
- Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis
- Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
- Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura
- Reduced plasma factor X is associated with a lack of response to recombinant activated factor VII in patients with hemophilia A and inhibitor, but does not impair emicizumab-driven hemostasis in vitro
- RIPK3 deficiency blocks R-2-hydroxyglutarate-induced necroptosis in IDH-mutated AML cells
- RNA splicing modulates the postharvest physiological deterioration of cassava storage root
- Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein
- Role of Rmd9p in 3'-end processing of mitochondrial 15S rRNA in Saccharomyces cerevisiae
- RSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells
- Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behçet's disease
- Serum vitamin D metabolite and acute-phase protein concentrations are frequently abnormal in a cohort of hospitalized dogs and cats
- Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
- Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
- SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing
- Study on the active components and mechanism of Atractylodis Macrocephalae Rhizoma for invigorating the spleen and tonifying qi based on spectrum-effect relationship and network pharmacology
- Surviving without BRCA2: MLH1 gets R-looped in to curtail genomic instability
- Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibiting TRIM25 oligomerization and functional activation of RIG-I/TRIM25
- Synthetic lethality: targeting SMARCA2 ATPase in SMARCA4-deficient tumors - a review of patent literature from 2019-30 June 2023
- Testing region selection and prognostic analysis of <em>MLH1</em> promoter methylation in colorectal cancer in China
- The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
- The Dual Role of Neutrophil Extracellular Traps (NETs) in Sepsis and Ischemia-Reperfusion Injury: Comparative Analysis across Murine Models
- The HLA-I landscape confers prognosis and antitumor immunity in breast cancer
- The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults
- The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
- THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling
- Therapeutic Options Targeting the Ataxia-Telangiectasia Mutated (ATM)-mediated DNA Damage Response, Macropinocytosis, and Adaptive Immunity in Ovarian Cancer
- Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
- Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice
- Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
- USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation
- Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblasti