• A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia
• alpha-Tocopherol and ascorbic acid prevent memory deficits provoked by chronic hyperprolinemia in rats
• Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
• Behavioral and neurochemical effects of proline
• Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish
• Biochemical and clinical features of hereditary hyperprolinemia
• Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
• Dietary treatment in hyperprolinaemia type II
• Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia
• Effect of proline on creatine kinase activity in rat brain
• Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome
• Evidence that hyperprolinemia alters glutamatergic homeostasis in rat brain: neuroprotector effect of guanosine
• Experimental hyperprolinemia induces mild oxidative stress, metabolic changes, and tissue adaptation in rat liver
• Familial hyperprolinemia, cerebral dysfunction and renal anomalies occurring in a family with hereditary nephropathy and deafness
• FAMILIAL HYPERPROLINEMIA. REPORT OF A SECOND CASE, ASSOCIATED WITH CONGENITAL RENAL MALFORMATIONS, HEREDITARY HEMATURIA AND MILD MENTAL RETARDATION, WITH DEMONSTRATION OF AN ENZYME DEFECT
• Free amino acids in extracts of cultured skin fibroblasts from patients with various amino acid metabolic disorders
• High urinary excretion of N-(pyrrole-2-carboxyl) glycine in type II hyperprolinemia
• Hydroxyproline metabolism in type II hyperprolinaemia
• Hyperleucinisoleucinemia due to partial transamination defect associated with type 2 hyperprolinemia. Familial case of double aminoacidopathy
• HYPERPROLINAEMIA AND HEREDITARY NEPHRITIS
• Hyperprolinaemia type 2
• Hyperprolinaemia type II
• Hyperprolinaemia: a disease which does not need treatment?
• Hyperprolinemia in Type 2 Glutaric Aciduria and MADD-Like Profiles
• Hyperprolinemia induces DNA, protein and lipid damage in blood of rats: antioxidant protection
• Hyperprolinemia type II: evidence of the excretion of 3-hydroxy delta 1-pyrroline 5-carboxylic acid
• Hyperprolinemia type II: identification of the glycine conjugate of pyrrole-2-carboxylic acid in urine
• Hyperprolinemic larvae of the drosophilid fly, Chymomyza costata, survive cryopreservation in liquid nitrogen
• Identification of PRODH mutations in Korean neonates with type I hyperprolinemia
• Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
• Inborn errors of proline metabolism
• Inhibition of Na+,K+-ATPase activity from rat hippocampus by proline
• Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome
• Long-term clinical outcome, therapy and mild mitochondrial dysfunction in hyperprolinemia
• Long-term neuropsychiatric follow-up in hyperprolinemia type I
• Metabolic epilepsy in hyperprolinemia type II due to a novel nonsense ALDH4A1 gene variant
• Metabolic studies in older mentally retarded patients: significance of metabolic testing and correlation with the clinical phenotype
• Mitochondrial proline dehydrogenase deficiency in hyperprolinemic PRO/Re mice: genetic and enzymatic analyses
• N-(pyrrole-2-carboxyl) glycine a diagnostic marker of hyperprolinaemia type II: mass spectra of trimethylsilyl derivatives
• Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
• New developments in diagnosis and treatment update: Schizophrenia/first episode psychosis in children and adolescents
• Novel variants in a patient with late-onset hyperprolinemia type II: diagnostic key for status epilepticus and lactic acidosis
• Physical exercise reverses cognitive impairment in rats subjected to experimental hyperprolinemia
• Proline administration decreases Na+,K+-ATPase activity in the synaptic plasma membrane from cerebral cortex of rats
• Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line
• Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: reversal by antipsychotic drugs
• Proline-induced inhibition of glutamate release in hippocampal area CA1
• Proline-induced potentiation of glutamate transmission
• Psychiatric phenotypes associated with hyperprolinemia: A systematic review
• Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood
• RENAL TUBULAR TRANSPORT OF PROLINE, HYDROXYPROLINE, AND GLYCINE IN HEALTH AND IN FAMILIAL HYPERPROLINEMIA
• Role of antioxidants on Na(+),K (+)-ATPase activity and gene expression in cerebral cortex of hyperprolinemic rats
• Screening for amino acid metabolic disorders of newborns in Zhejiang province:prevalence, outcome and follow-up
• Selective Screening for Organic Acidurias and Amino Acidopathies in Pakistani Children
• Single amino acid polymorphism in aldehyde dehydrogenase gene superfamily
• Structure, function, and mechanism of proline utilization A (PutA)
• The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD
• The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans
• The three-dimensional structural basis of type II hyperprolinemia
• Type 2 hyperprolinemia: absence of delta1-pyrroline-5-carboxylic acid dehydrogenase activity
• Type I hyperprolinemia. Study of a familial case
• Type II hyperprolinemia: a case report
• Vitamin B6 related epilepsy during childhood
• Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association