• (<em>S</em>)-5-(2'-Fluorophenyl)-<em>N</em>,<em>N</em>-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an <em
• (S)-5-(2'-Fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Fmr1 Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum D
• <em>Cyfip1</em> Haploinsufficiency Does Not Alter GABA_A Receptor δ-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV⁺ Interneurons and Granule Cells
• 2D and 3D FISH of expanded repeat RNAs in human lymphoblasts
• A single episode of early-life status epilepticus impacts neonatal ultrasonic vocalization behavior in the Fmr1 knockout mouse
• Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety
• Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders
• Altered A-Type Potassium Channel Function Impairs Dendritic Spike Initiation and Temporoammonic Long-Term Potentiation in Fragile X Syndrome
• Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome
• Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome
• Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome
• Between Order and Chaos: Understanding the Mechanism and Pathology of RAN Translation
• Brain Metabolomics in Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)
• Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP
• Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis
• CGG Repeat Expansion, and Elevated <em>Fmr1</em> Transcription and Mitochondrial Copy Number in a New Fragile X PM Mouse Embryonic Stem Cell Model
• Clinical and genetic characteristics of 9 rare cases with coexistence of dual genetic diagnoses
• Clinical and Molecular Assessment in a Female with Fragile X Syndrome and Tuberous Sclerosis
• Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin-two cases
• Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1
• Deletion of TOP3B Is Associated with Cognitive Impairment and Facial Dysmorphism
• Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
• Detection of long repeat expansions from PCR-free whole-genome sequence data
• Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders
• Dysregulated cholesterol metabolism, aberrant excitability and altered cell cycle of astrocytes in fragile X syndrome
• Early 7,8-Dihydroxyflavone Administration Ameliorates Synaptic and Behavioral Deficits in the Young FXS Animal Model by Acting on BDNF-TrkB Pathway
• Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the <em>Fmr1</em>-KO Mouse Model of Fragile X Syndrome
• Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
• Effects of AFQ056 on language learning in fragile X syndrome
• Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance
• Effects of Soy Protein Isolate on Fragile X Phenotypes in Mice
• Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy
• Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice
• Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein
• Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
• ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model
• Exploring microbiota-gut-brain axis biomarkers linked to autism spectrum disorder in prenatally chlorpyrifos-exposed Fmr1 knock-out and wild-type male rats
• FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission
• FMRP regulates presynaptic localization of neuronal voltage gated calcium channels
• Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes
• Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis
• Fragile X syndrome: An overview and update of the FMR1 gene
• FXTAS Neuropathology Includes Widespread Reactive Astrogliosis and White Matter Specific Astrocyte Degeneration
• Gaboxadol in Fragile X Syndrome: A 12-Week Randomized, Double-Blind, Parallel-Group, Phase 2a Study
• Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs
• High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups
• HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein
• Hyperactive locomotion in a <em>Drosophila</em> model is a functional readout for the synaptic abnormalities underlying fragile X syndrome
• Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome
• Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain
• Impaired AMPARs Translocation into Dendritic Spines with Motor Skill Learning in the Fragile X Mouse Model
• Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible
• Increased transient Na(+) conductance and action potential output in layer 2/3 prefrontal cortex neurons of the fmr1(-/y) mouse
• Increased transient Na⁺ conductance and action potential output in layer 2/3 prefrontal cortex neurons of the fmr1^-/y mouse
• Inequities in diagnosis of Fragile X syndrome in Colombia
• Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial
• Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome
• KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo
• Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice
• Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease
• Magnetic Nanoparticle-Based Mechanical Stimulation for Restoration of Mechano-Sensitive Ion Channel Equilibrium in Neural Networks
• Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity
• Metformin ameliorates core deficits in a mouse model of fragile X syndrome
• Metformin as targeted treatment in fragile X syndrome
• Metformin treatment in young children with fragile X syndrome
• Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
• Multidimensional Analysis of a Social Behavior Identifies Regression and Phenotypic Heterogeneity in a Female Mouse Model for Rett Syndrome
• Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome
• Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice
• Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage
• New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein
• New Insights Into the Role of Ca(v)2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons
• New Insights Into the Role of Ca_v2 Protein Family in Calcium Flux Deregulation in <em>Fmr1</em>-KO Neurons
• Noninvasive prenatal diagnosis of genetic diseases induced by triplet repeat expansion by linked read haplotyping and Bayesian approach
• Oral language interventions can improve language outcomes in children with neurodevelopmental disorders: A systematic review and meta-analysis
• Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats
• PGC-1alpha integrates insulin signaling with mitochondrial physiology and behavior in a Drosophila model of Fragile X Syndrome
• Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder
• Phosphodiesterase 4D activity in acrodysostosis-associated neural pathology: too much or too little?
• Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases
• Prader-Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review
• Preferences for Accessing Electronic Health Records for Research Purposes: Views of Parents Who Have a Child With a Known or Suspected Genetic Condition
• Preferences for the research use of electronic health records among young adults with fragile X syndrome or autism spectrum disorder
• Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome
• Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex
• Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP
• Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain
• Significance and case analysis of FMR1 mutation screening during early and middle pregnancy
• Skeletal muscle proteome expression differentiates severity of cancer cachexia in mice and identifies loss of fragile X mental retardation syndrome-related protein 1
• Spontaneous Activity Patterns Are Altered in the Developing Visual Cortex of the <em>Fmr1</em> Knockout Mouse
• Subtle differences in synaptic transmission in medial nucleus of trapezoid body neurons between wild-type and Fmr1 knockout mice
• Tactile Defensiveness and Impaired Adaptation of Neuronal Activity in the <em>Fmr1</em> Knock-Out Mouse Model of Autism
• Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model
• The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice
• Transient Enhanced GluA2 Expression in Young Hippocampal Neurons of a Fragile X Mouse Model
• Transient Potassium Channels: Therapeutic Targets for Brain Disorders
• Treating a novel plasticity defect rescues episodic memory in Fragile X model mice
• Urine microRNA Profiling Displays miR-125a Dysregulation in Children with Fragile X Syndrome
• Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome
• Visual Experience-Dependent Oscillations and Underlying Circuit Connectivity Changes Are Impaired in Fmr1 KO Mice