Research By Disease – CheckOrphan

Disease: Familial adenomatous polyposis

Antrodia camphorata Supplementation during Early Life Alters Gut Microbiota and Inhibits Young-Onset Intestinal Tumorigenesis in APC1638N Mice Later in Life
Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling
In silico evaluation of anti-colorectal cancer inhibitors by Resveratrol derivatives targeting Armadillo repeats domain of APC: molecular docking and molecular dynamics simulation
A case of an unreported point mutation in promoter 1B of the adenomatous polyposis coli gene, which is responsible for gastric adenocarcinoma and proximal polyposis of the stomach
A Case of Cribriform-Morular Thyroid Carcinoma Presenting Without Thyroid Nodule
A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation
Ampullary tumors: French Intergroup Clinical Practice Guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, ACHBT, AFC, SFRO, RENAPE, SNFCP, AFEF, SFP, SFR)
An In Vivo Metastasis Model Using Genotype-Defined Tumor Organoids
Anti-LINGO-1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke
Association of genetic ancestry with molecular tumor profiles in colorectal cancer
Attenuated adenomatous polyposis with MSH6 variation: Two case reports
Atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory receptor neurons
Autistic traits in youth with familial adenomatous polyposis: A Dutch-Canadian case-control study
Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss
Black raspberry-mediated metabolic changes in patients with familial adenomatous polyposis associated with rectal polyp regression
Case report: Initial atypical skeletal symptoms and dental anomalies as first signs of Gardner syndrome: the importance of genetic analysis in the early diagnosis
Challenges in developing and implementing international best practice guidance for intermediate-risk variants in cancer susceptibility genes: APC c.3920T>A p.(Ile1307Lys) as an exemplar
Chemoprevention in Inherited Colorectal Cancer Syndromes
Classification of fundic gland polyps for predicting gastric neoplasms in Helicobacter pylori-negative patients with familial adenomatous polyposis
Clinical and Immunologic Characteristics of Colorectal Cancer Tumors Expressing LY6G6D
Colocolonic intussusception as initial manifestation of polyposis coli associated colon cancer
Continuing Medical Education Questions: April 2024
Could Capsule Endoscopy Be Useful in Detection of Suspected Small Bowel Bleeding and IBD-10 Years of Single Center Experience
Cribriform morular thyroid carcinoma: Clinicopathological and molecular basis for both a preventive and therapeutic approach for a rare tumor (Review)
Current management of familial adenomatous polyposis
Dealing with plasmonic crystal biosensors: Sensitivity assessment of nanodisks/nanoholes arrayed plasmonic system for label-free DNA detection
Delta-like noncanonical notch ligand 2 regulates the proliferation and differentiation of sheep myoblasts through the Wnt/β-catenin signaling pathway
Development of an in vivo syngeneic mouse transplant model of invasive intestinal adenocarcinoma driven by endogenous expression of Pik3caH1047R and Apc loss
Development of Desmoid Tumors After Ileorectal Anastomosis Versus Ileal Pouch-Anal Anastomosis in Familial Adenomatous Polyposis
Development of desmoid tumours after ileorectal anastomosis versus ileal pouch-anal anastomosis in familial adenomatous polyposis
Diagnosis and treatment of primary ileal pouch leaks: a 27-year experience at a referral center
Diagnosis, treatment, and prognosis of adult pancreatoblastoma
Diffuse familial adenomatous intestinal polyposis in childhood: current state of the problem and case report
Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells
Dual primary gastric and colorectal cancer: The known hereditary causes and underlying mechanisms
Dynamics of the gut microbiome in FAP patients undergoing intensive endoscopic reduction of polyp burden
Effect of genetic profiling on surgical decisions at hereditary colorectal cancer syndromes
Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice
Endoscopic indicators in patients with familial adenomatous polyposis undergoing duodenal resections - a nationwide Danish cohort study with long-term follow-up
Endoscopic management of patients with familial adenomatous polyposis after prophylactic colectomy or restorative proctocolectomy - systematic review of the literature
Endoscopic scoring indices for assessing disease severity in familial adenomatous polyposis: Systematic review
Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells
Erratum: Solving Missing Heritability in Patients With Familial Adenomatous Polyposis With DNA-RNA Paired Testing
Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes
Evolutionary history of adenomas to colorectal cancer in FAP families
Exploring Familial Adenomatous Polyposis Through Radiology: A Case Series and Literature Review
Exploring the DNA Methylation Profile of Genes Associated with Bladder Cancer in Bladder Tissue of Patients with Neurogenic Lower Urinary Tract Dysfunction
Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice
Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review
Genomic insights into familial adenomatous polyposis: unraveling a rare case with whole APC gene deletion and intellectual disability
Gut microbiota and serum metabolite signatures along the colorectal adenoma-carcinoma sequence: Implications for early detection and intervention
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes
Identification of a novel germline APC N-terminal pathogenic variant associated with attenuated familial adenomatous polyposis
Ileal pouch adenocarcinoma after restorative proctocolectomy for familial adenomatous polyposis
Immune profiling of premalignant lesions in patients with Peutz-Jeghers syndrome
Impact of Endoscopic Treatment in Severe Duodenal Polyposis: A National Study in Familial Adenomatous Polyposis Patients
Incidence of common gene mutations in early-onset colorectal cancer and the association with cancer survival: a meta-analysis
Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention
Management of Desmoid Disease in Familial Adenomatous Polyposis
Marital status after colorectal surgery in familial adenomatous polyposis: a nationwide multicenter study in Japan
Mechanisms of Action of Phytoestrogens and Their Role in Familial Adenomatous Polyposis
Mechanistic exploration of 6-shogaol's preventive effects on azoxymethane and dextran sulfate sodium -induced colorectal cancer: involvement of cell proliferation, apoptosis, carcinoembryonic antigen, wingless-related integration site signaling, and
Mixed adenoma-neuroendocrine tumor of the stomach: analysis of nine cases with literature review
Molecular Demonstration of the Tumorigenic Role of APC in Pancreatic Solid Pseudopapillary Neoplasm Widens the Spectrum of FAP-Associated Neoplasms
Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets
Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor
Nanoimprinted Plasmonic Crystals for Cost-Effective SERS Identification of Methylated DNAs
Navigating Progress: Eight-Year Single-Center Experience With Minimally Invasive Proctectomy and Ileal Pouch-Anal Anastomosis
Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation
Outcomes following duodenectomy in patients with familial adenomatous polyposis
Paraspinal Desmoid Tumor in a Pediatric Patient with No Surgical History: A Case Report
Phenotype correlations with pathogenic DNA variants in the MUTYH gene
PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis
Plasma ctDNA enhances the tissue-based detection of oncodriver mutations in colorectal cancer
Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APCMin/+ Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-κB Signaling Pathway
Pouch abandonment is extremely rare even in the reoperative setting: A high-volume referral center experience
Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer
Predictive modeling for the germline pathogenic variant of the APC gene in patients with adenomatous polyposis: proposing a new APC score
Progression of Nodular Thyroid Disease in Familial Adenomatous Polyposis Syndrome: Refined Surveillance Recommendations
Rare Germline Variants in the Adenomatous Polyposis Coli Gene Associated with Dental and Osseous Anomalies
Rediversion of the Failing Ileoanal Pouch: First Step in Pouch Salvage?
Regulation of eukaryotic transcription initiation in response to cellular stress
Robotic-assisted reoperative ileal pouch-anal anastomosis: robotic pouch excision and pouch revision
Solving Missing Heritability in Patients With Familial Adenomatous Polyposis With DNA-RNA Paired Testing
Superficial fibromas with CTNNB1 mutation
Surgical Decision-Making in Familial Adenomatous Polyposis
Systematic large-scale application of ClinGen InSiGHT APC -specific ACMG/AMP variant classification criteria substantially alleviates the burden of variants of uncertain significance in ClinVar and LOVD databases
Targeted genotyping for recurring variants in cancer susceptibility genes in non-Ashkenazi Jewish patients with breast cancer diagnosed ≥50 years
Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
The Duodenal Accessory Ampulloma and the Role of Endoscopic Retrograde Cholangiopancreatography (ERCP) in Familial Adenomatous Polyposis Coli Inheritance
The KRAS G12D mutation increases the risk of unresectable recurrence of resectable colorectal liver-only metastasis
Tumor invasiveness is regulated by the concerted function of APC, formins, and Arp2/3 complex
Two Cases of Increased Gastrointestinal Polyps in Familial Adenomatous Polyposis following Antiacid Agent Intake
Two Distinct Characteristics of Immune Microenvironment in Human Hepatocellular Carcinoma with Wnt/β-Catenin Mutations
Unraveling the Mystery of Desmoid Tumors: Insights From a Moroccan Tertiary Center
Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-E
Which Drugs are More Effective in Preventing Familial Adenomatous Polyposis Progression based on Network Meta-analysis?
Yogurt Prevents Colorectal Tumorigenesis in ApcMin/+ Mice