Disease: Cholesterol esterification disorder
- <em>Acat1/Soat1</em> knockout extends the mutant <em>Npc1</em> mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells
- 25-Hydroxycholesterol in health and diseases
- A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
- A Phytosterolemic Mixture of Sterols Inhibits Cholesterol Synthesis, Esterification, and Low-Density Lipoprotein Receptor mRNA Abundance in HepG2 Cells
- Abnormal histidine metabolism promotes macrophage lipid accumulation under Ox-LDL condition
- Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound
- Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era
- Adult-onset Niemann-Pick disease type C masquerading as spinocerebellar ataxia
- An Analysis of Isolated and Intact RBC Membranes-A Comparison of a Semiquantitative Approach by Means of FTIR, Nano-FTIR, and Raman Spectroscopies
- Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma
- Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification
- Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells
- Bacillus amyloliquefaciens Protect Against Atherosclerosis Through Alleviating Foam Cell Formation and Macrophage Polarization
- Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation
- Cholesterol esterification and p53-mediated tumor suppression
- Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression
- Clinical disease progression and biomarkers in Niemann-Pick disease type C: a prospective cohort study
- Copeptin - a biomarker of short-term mortality risk (7 days) in patients with end-stage liver disease
- Current Status of Familial LCAT Deficiency in Japan
- Delineation of metabolic responses of Npc1(-/-nih) mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-beta-cyclodextrin
- Delineation of metabolic responses of Npc1<sup>-/-nih</sup> mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin
- Depletion of Cholesteryl Esters Causes Meibomian Gland Dysfunction-Like Symptoms in a <em>Soat1</em>-Null Mouse Model
- Dietary calcium affects body composition and lipid metabolism in rats
- Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
- Effect of Carotenoids from <em>Phaeodactylum tricornutum</em> on Palmitate-Treated HepG2 Cells
- Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice
- Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function
- Esterification of 4beta-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
- Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
- Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism
- Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations
- Foam Cells as Therapeutic Targets in Atherosclerosis with a Focus on the Regulatory Roles of Non-Coding RNAs
- From Inert Storage to Biological Activity-In Search of Identity for Oxidized Cholesteryl Esters
- G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes
- Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice
- Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis
- Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
- Hepatocyte-Specific <em>Fads1</em> Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model
- High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (<em>Oreochromis niloticus</em>)
- High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus)
- High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer
- High-density lipoproteins, reverse cholesterol transport and atherogenesis
- How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses
- Induction of microRNA hsa-let-7d-5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage 'foam' cells
- Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis
- Inhibitory effect of modified silkworm pupae oil in PDGF-BB-induced proliferation and migration of vascular smooth muscle cells
- Integration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer
- Intracellular Cholesterol Synthesis and Transport
- LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis
- LDL Promotes Disorders in beta-Cell Cholesterol Metabolism, Implications on Insulin Cellular Communication Mediated by EVs
- LDL Promotes Disorders in β-Cell Cholesterol Metabolism, Implications on Insulin Cellular Communication Mediated by EVs
- Lecithin-Cholesterol Acyltransferase Deficiency
- Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study
- Mechanisms and regulation of cholesterol homeostasis
- Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
- Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK/ERK signaling pathway in ox‑LDL‑induced THP‑1 monocytes
- Methionine sulfoxide reductase A attenuates atherosclerosis via repairing dysfunctional HDL in scavenger receptor class B type I deficient mice
- Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention
- Molecular insights of cigarette smoke condensate-activated NLRP3 inflammasome in THP-1 cells in a stage-specific atherogenesis
- Molecular structures of human ACAT2 disclose mechanism for selective inhibition
- mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts
- Novel insights: Dynamic foam cells derived from the macrophage in atherosclerosis
- P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis
- Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers - A Systematic Review
- Palmitoleic Acid Decreases Non-alcoholic Hepatic Steatosis and Increases Lipogenesis and Fatty Acid Oxidation in Adipose Tissue From Obese Mice
- PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium
- PLA2G15 is a Lysosomal BMP Hydrolase with Ester Position Specificity and its Targeting Ameliorates Lysosomal Disease
- Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer's disease
- Progesterone Suppresses Cholesterol Esterification in APP/PS1 mice and a cell model of Alzheimer's Disease
- Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover
- Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator
- Resistance to Cholesterol Gallstone Disease: Hepatic Cholesterol Metabolism
- Revisiting Reverse Cholesterol Transport in the Context of High-Density Lipoprotein Free Cholesterol Bioavailability
- Role of sortilin 1 (SORT1) on fatty acid-mediated cholesterol metabolism in primary calf hepatocytes
- Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection
- Sex-Specific Dysregulation of Placental Lipid Metabolism in Preeclampsia
- Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice
- Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid beta-oxidation and inducing lipotoxicity
- Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity
- Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress-Brief Report
- Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma
- Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses
- Structure of nevanimibe-bound tetrameric human ACAT1
- Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats
- Systematic evaluation of the effect of different apolipoprotein A-I mimetic peptides on the performance of synthetic high-density lipoproteins in vitro and in vivo
- Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation
- The Adaptive Characteristics of Cholesterol and Bile Acid Metabolism in Nile Tilapia Fed a High-Fat Diet
- The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking
- The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer
- The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier <em>in vitro</em>
- The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann-Pick Disease: A Comprehensive Review
- The metabolic adaptation of bile acids and cholesterol after biliary atresia in lamprey via transcriptome-based analysis
- The mitochondrial calcium signaling, regulation, and cellular functions: A novel target for therapeutic medicine in neurological disorders
- The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
- The potential role and mechanism of circRNAs in foam cell formation
- Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency
- VHL mutation drives human clear cell renal cell carcinoma progression through PI3K/AKT-dependent cholesteryl ester accumulation
- Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress
- Vitamin D and Atherosclerosis: Unraveling the Impact on Macrophage Function
- What the (abdominal) surgeon needs to know on novel insights regarding cholic acids and their interaction with the intestinal microbioma