• A Rare Clinical Finding in Ataxia Telangiectasia: Granulomatous Skin Lesion
• Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice
• Alantolactone Induced Apoptosis and DNA Damage of Cervical Cancer through ATM/CHK2 Signaling Pathway
• ARID1A is involved in DNA double-strand break repair in gastric cancer
• Assessment of genome mutation analysis for tumor-informed detection of circulating tumor DNA in patients with breast cancer
• Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress
• Ataxia telangiectasia-mutated rs56009889 and risk of common cancers
• Ataxia-telangiectasia in Latin America: clinical features, immunodeficiency, and mortality in a multicenter study
• Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications
• ATAXIA-telangiectasia with compound heterozygous ATM mutations discovered on abnormal newborn screen
• ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination
• ATM dysfunction in Chinese hamster XRCC8 mutants
• ATM facilitates autophagy and protects against oxidative stress and apoptosis in response to ER stress in vitro
• ATM germline pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies
• ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
• ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma
• ATM-dependent Phosphorylation of Nemo SQ Motifs Is Dispensable for Nemo-mediated Gene Expression Changes in Response to DNA Double-Strand Breaks
• ATM, BLM, and CDH1 gene co-mutations in a high-grade endometrial stromal sarcoma patient with multiple abdominal cavity metastases: a case report and literature review
• Atrx loss as a promising screening tool for the identification of diffuse midline glioma subtype, H3K27/MAPKinase co-altered
• Bayesian meta-analysis of penetrance for cancer risk
• Case report: Compound heterozygous variants detected by next-generation sequencing in a Tunisian child with ataxia-telangiectasia
• Case report: Innovative treatment for one metastatic thyroid-like follicular carcinoma of the kidney with <em>ATM</em> and <em>POLE</em> mutations
• Clinical and genetic spectrum of Ataxia Telangiectasia Tunisian patients: Bioinformatic analysis unveil mechanisms of ATM variants pathogenicity
• Cyclic Vomiting Syndrome as a New Phenotype of Ataxia-Telangiectasia Syndrome
• Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies
• Distinct regulation of ATM signaling by DNA single-strand breaks and APE1
• DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops
• Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer
• Dual-targeting class I HDAC inhibitor and ATM activator, SP-1-303, preferentially inhibits estrogen receptor positive breast cancer cell growth
• Early inhibition of the ATM/p53 pathway reduces the susceptibility to atrial fibrillation and atrial remodeling following acute myocardial infarction
• Exo1 cooperates with Tel1/ATM in promoting recombination events at DNA replication forks
• Faulty Gap Filling in Nucleotide Excision Repair Leads to Double-Strand Break Formation in Senescent Cells
• Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study
• Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma
• Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy
• Germline mutations of breast cancer susceptibility genes through expanded genetic analysis in unselected Colombian patients
• Germline pathogenic variants of cancer predisposition genes in a multicentre Italian cohort of pancreatic cancer patients
• H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
• Hematopoietic stem/progenitor cell transplantation recovers immune defects and prevents lymphomas in Atm-deficient mice
• Her Legacy Lives On: Celebrating the Women Behind Head and Neck Eponyms
• Identification of ATM Mutation as a Potential Prognostic Biomarker for Immune Checkpoint Inhibitors Therapy
• Immune profiling and functional analysis of NK and T cells in ataxia telangiectasia
• Impact of homologous recombination repair/BReast CAncer (BRCA) gene alterations on survival in a real-world setting of metastatic prostate cancer
• Inhibition of aberrantly overexpressed Polo-like kinase 4 is a potential effective treatment for DNA damage repair-deficient uterine leiomyosarcoma
• Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
• Inhibition of ribonucleotide reductase subunit M2 enhances the radiosensitivity of metastatic pancreatic neuroendocrine tumor
• Inhibition of the ATR-DNAPKcs-RB axis drives G1/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions
• Inhibitors of APE1 redox and ATM synergistically sensitize osteosarcoma cells to ionizing radiation by inducing ferroptosis
• Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
• Kaempferol from Alpinia officinarum hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway
• Late-Onset Ataxia-Telangiectasia Presenting With Dystonia and Tremor: The Use of Nanopore Long-Read Sequencing Solving the Variant Phase
• Lessons from the ATTeST trial in ataxia telangiectasia
• LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer
• Multilocus inherited neoplasia allele syndrome: report of uncommon combinations between <em>CHEK2/ATM</em> and <em>BRCA1/CDKN2A</em> genes
• Mutational profile of primary clear cell renal cell carcinoma predicts recurrence and potential candidacy for adjuvant immune checkpoint inhibition
• Myeloid neoplasms in individuals with breast and ovarian cancer and the association with deleterious germline variants
• New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B
• Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial
• Oleandrin enhances radiotherapy sensitivity in lung cancer by inhibiting the ATM/ATR-mediated DNA damage response
• Optimizing ATR Inhibition and Cisplatin Synergy in Ewing Sarcoma
• Oxidative stress and the multifaceted roles of ATM in maintaining cellular redox homeostasis
• PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation
• Polo-Like Kinase 1 and DNA Damage Response
• Post-Integrational DNA Repair of HIV-1 Is Associated with Activation of the DNA-PK and ATM Cellular Protein Kinases and Phosphorylation of Their Targets
• Preclinical Systemic Pharmacokinetics, Dose Proportionality, and Central Nervous System Distribution of the ATM Inhibitor WSD0628, a Novel Radiosensitizer for the Treatment of Brain Tumors
• Preclinical systemic pharmacokinetics, dose-proportionality, and CNS distribution of the ATM inhibitor WSD0628, a novel radiosensitizer for the treatment of brain tumors
• Primary Immunodeficiency-Type Ataxia-Telangiectasia Revealed by Splenic Abscesses
• Progress of ATM inhibitors: Opportunities and challenges
• PTEN Depletion Increases Radiosensitivity in Response to Ataxia Telangiectasia-Related-3 (ATR) Inhibition in Non-Small Cell Lung Cancer (NSCLC)
• Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder
• RNA demethylase FTO participates in malignant progression of gastric cancer by regulating SP1-AURKB-ATM pathway
• RNA editing landscape of adipose tissue in polycystic ovary syndrome provides insight into the obesity-related immune responses
• Role of 4-Thiazolidinone-Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines
• Safety and efficacy of intra-erythrocyte dexamethasone sodium phosphate in children with ataxia telangiectasia (ATTeST): a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
• Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy
• SLFN11 and ATR as targets for overcoming cisplatin resistance in ovarian cancer cells
• Small Molecular Inhibitors That Target ATM for Drug Discovery: Current Research and Potential Prospective
• SMARCA2 and SMARCA4 Participate in DNA Damage Repair
• Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline <em>ATM</em> sequence variants
• Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins
• Targeted sequencing of DNA/RNA combined with radiomics predicts lymph node metastasis of papillary thyroid carcinoma
• Targeting shelterin proteins for cancer therapy
• Targeting the ATM pathway in cancer: Opportunities, challenges and personalized therapeutic strategies
• The DNA repair kinase ATM regulates CD13 expression and cell migration
• The DNA repair pathway as a therapeutic target to synergize with trastuzumab deruxtecan in HER2-targeted antibody-drug conjugate-resistant HER2-overexpressing breast cancer
• The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
• The Effects and Mechanism of ATM Kinase Inhibitors in <em>Toxoplasma gondii</em>
• The emerging role of Schlafen-11 (SLFN11) in predicting response to anticancer treatments: Focus on small cell lung cancer
• The guidelines for clinical practice for carriers of germline mutations in hereditary breast, ovarian, prostate, and pancreatic cancer predisposition genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 (4.2024)
• The importance of synthetic pharmacotherapy for recessive cerebellar ataxias
• The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
• The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
• The sufficiency of genetic diagnosis in managing patients with inborn errors of immunity during prenatal care and childbearing
• TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
• UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
• Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of <em>BRCA2</em>^MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors
• Use of Radiation Therapy for Ataxia-Telangiectasia Mutated (ATM)-Mutation Metastatic Renal Cell Carcinoma: A Case Report
• Venetoclax use in a patient with ataxia telangiectasia and early T-cell precursor acute lymphoblastic leukemia
• Whole genome joint analysis reveals ATM:C.1564_1565del variant segregating with Ataxia-Telangiectasia and breast cancer
• Widespread chromatin context-dependencies of DNA double-strand break repair proteins