Disease: Ataxia-Telangiectasia
- <em>ATM</em>-the gene at the moment in non-small cell lung cancer
- <em>Helicobacter pylori</em> Eradication Reverses DNA Damage Response Pathway but Not Senescence in Human Gastric Epithelium
- <em>Toxoplasma gondii</em> infection-induced host cellular DNA damage is strain-dependent and leads to the activation of the ATM-dependent homologous recombination pathway
- A novel approach using ATR-FTIR spectroscopy and chemometric analysis to distinguish male and female human hair samples
- A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization
- A Review of the Repair of DNA Double Strand Breaks in the Development of Oral Cancer
- A-T neurodegeneration and DNA damage-induced transcriptional stress
- Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization
- Absence of ATM leads to altered NK cell function in mice
- Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer
- Aluminium phthalocyanine-mediated photodynamic therapy induces ATM-related DNA damage response and apoptosis in human oesophageal cancer cells
- Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
- Ataxia telangiectasia: a rare case report from Nepal
- Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells
- Ataxia-Telangiectasia Mutated (ATM) loss of function displays variant and tissue-specific differences across tumor types
- ATM deficiency differentially affects expression of proteins related to fatty acid oxidation and oxidative stress in a sex-specific manner in response to Western-type diet prior to and following myocardial infarction
- ATM Variant as a Cause of Hereditary Cutaneous Melanoma in a Spanish Family: Case Report
- ATR blocks telomerase from converting DNA breaks into telomeres
- ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability
- ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair
- AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia-mediated neuroinflammation and ischemic brain injury
- Bilateral diffuse metastases in advanced lung adenocarcinoma harboring EGFR mutations was associated with a favorable prognosis to EGFR-TKIs
- BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes
- Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation
- Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity
- Cigarette smoking inhibits myoblast regeneration by promoting proteasomal degradation of NPAT protein and hindering cell cycle progression
- Cinchophen induces RPA1 related DNA damage and apoptosis to impair ENS development of zebrafish
- Circ_0008657 regulates lung DNA damage induced by hexavalent chromium through the miR-203a-3p/ATM axis
- Clinical characteristics of BRAT1-related disease: a systematic literature review
- Computational Analysis of Non-synonymous SNPs in ATM Kinase: Structural Insights, Functional Implications, and Inhibitor Discovery
- Context matters: DNA virus infection reshapes DNA damage response pathways
- Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest
- Defining the progeria phenome
- Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)
- Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase
- Differential diagnosis of Crohn's disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning
- Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis-dependent intervertebral disc inflammatory degeneration
- Discovery of Selective and Potent ATR Degrader for Exploration its Kinase-Independent Functions in Acute Myeloid Leukemia Cells
- Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment
- Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation
- Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2
- DNA Damage-driven Inflammatory Cytokines: Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy
- DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish
- DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
- Does the role of non-coding RNA FAM131B-AS2 in glioblastoma go beyond the ATR pathway? A correspondence
- Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial
- Epstein-Barr virus-associated smooth muscle tumor in a female with ataxia telangiectasia: A case report
- Evaluation of Ataxia-Telangiectasia Mutated IVS10 Mutation in Breast Cancer Along with Clinicopathological Parameters
- Evidence for persistent UV-induced DNA damage and altered DNA damage response in xeroderma pigmentosa patient corneas
- Exploring machine learning for untargeted metabolomics using molecular fingerprints
- Ferritinophagy Is Critical for Deoxynivalenol-Induced Liver Injury in Mice
- First-in-Human Study of the Ataxia Telangiectasia and Rad3-related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
- Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
- Genomic characterization and detection of potential therapeutic targets for peritoneal mesothelioma in current practice
- Germline variants of DNA repair and immune genes in lymphoma from lymphoma-cancer families
- GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound healing
- Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
- Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
- Identification of Two Novel Pathogenic Variants of the <em>ATM</em> Gene in the Iranian-Azeri Turkish Ethnic Group by Applying Whole Exome Sequencing
- Integrated bioinformatics approach to unwind key genes and pathways involved in colorectal cancer
- Intestinal lysozyme1 deficiency alters microbiota composition and impacts host metabolism through the emergence of NAD<sup>+</sup>-secreting <em>ASTB Qing110</em> bacteria
- Mechanism of Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair
- Monitoring Chk1 kinase activity dynamics in live single cell imaging assays
- Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells
- Potentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer
- Predictive DNA damage signaling for low‑dose ionizing radiation
- Promising Response of Olaparib in Patient With Germline <em>ATM</em>-Mutated Metastatic Gastric Cancer
- Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway
- Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses
- Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase
- Research Progress in the Roles of MRE11-RAD50-NBS1 Complex and Human Diseases
- Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts
- Safety of the Breast Cancer Adjuvant Radiotherapy in Ataxia-Telangiectasia Mutated Variant Carriers
- Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
- Study of Monoclonal Antibody Aggregation at the Air-Liquid Interface under Flow by ATR-FTIR Spectroscopic Imaging
- Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells
- Targeting ATR in patients with cancer
- Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes
- Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair
- The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence
- The ATR inhibition by Elimusertib enhances the radiosensitivity of MDA-MB-231 triple negative breast cancer in vitro
- The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment
- The clinical spectrum of ataxia telangiectasia in a cohort in Sweden
- The KRAS, ATR and CHEK1 expression levels in endometrial cancer are the risk factors predicting recurrence
- The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma
- The novel ATR inhibitor M1774 induces replication protein overexpression and broad synergy with DNA-targeted anticancer drugs
- The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
- The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation
- Therapeutic Options Targeting the Ataxia-Telangiectasia Mutated (ATM)-mediated DNA Damage Response, Macropinocytosis, and Adaptive Immunity in Ovarian Cancer
- TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2
- Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia
- TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma
- Triple-Negative Breast Cancer and Emerging Therapeutic Strategies: ATR and CHK1/2 as Promising Targets
- Trypanosoma cruzi infection induces DNA double-strand breaks and activates DNA damage response pathway in host epithelial cells
- Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
- Unraveling the molecular landscape of Ataxia Telangiectasia: Insights into Neuroinflammation, immune dysfunction, and potential therapeutic target
- Variant ataxia telangiectasia identified during evaluation for short stature
- Videoocular assessment of eye movement activity in an ataxia-telangiectasia: a case study
- Zeocin-induced DNA damage response in barley and its dependence on ATR
- ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway