Research By Disease – CheckOrphan

Disease: African trypanosomiasis

Trypanosoma brucei multi-aminoacyl-tRNA synthetase complex formation limits promiscuous tRNA proofreading
A man in his sixties with life-threatening febrile illness after travel abroad
A Nanobody/Monoclonal Antibody "hybrid" sandwich technology offers an improved immunoassay strategy for detection of African trypanosome infections
A scoping review on tsetse fly blood meal sources and its assay methods since 1956 to 2022
Adipose and skin distribution of African trypanosomes in natural animal infections
Advancement in the development of DNA vaccines against Trypanosoma brucei and future perspective
An In vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl
Animal models of neglected parasitic diseases: In vivo multimodal imaging of experimental trypanosomatid infections
Animal trypanosomosis eliminated in a major livestock production region in Senegal following the eradication of a tsetse population
Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae): A review of the traditional uses, phytochemistry and pharmacology of African birch
Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhode
Antitrypanosomal Chloronitrobenzamides
APOL1-Mediated Kidney Disease
Ascofuranone antibiotic is a promising trypanocidal drug for nagana
Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes
Cardiac involvement in Chagas disease and African trypanosomiasis
Caught in a trap: DNA contamination in tsetse xenomonitoring can lead to over-estimates of Trypanosoma brucei infection
Comparison of stochastic and deterministic models for gambiense sleeping sickness at different spatial scales: A health area analysis in the DRC
Comparison of Three Widely Employed Extraction Methods for Metabolomic Analysis of Trypanosoma brucei
Conducting active screening for human African trypanosomiasis with rapid diagnostic tests: The Guinean experience (2016-2021)
Consistent detection of Trypanosoma brucei but not T. congolense DNA in faeces of experimentally infected cattle
Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies
Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies
Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computational and In Vitro Assessment
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
Discovery of 1,3,4-Oxadiazole Derivatives as Broad-Spectrum Antiparasitic Agents
Discovery of Strong 3-Nitro-2-Phenyl-2H-Chromene Analogues as Antitrypanosomal Agents and Inhibitors of Trypanosoma cruzi Glucokinase
Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion
Diversity of Glossinidae (Diptera) species in The Gambia in relation to vegetation
Eflornithine for treatment of high-risk neuroblastoma
Elimination of human African trypanosomiasis: The long last mile
Epidemiological study on cattle trypanosomiasis and its vectors distributions in the Gambella regional state, southwestern Ethiopia
Evaluating for correlations between metabolites in patients receiving immunotherapy for metastatic or recurrent NSCLC: an exploratory study based on two cohorts
Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Evaluation of ITS1 rDNA primers for the detection and identification of African trypanosomes in mammalian hosts and tsetse flies
Evaluation of the International Task Force for Disease Eradication: A Review of Past Deliberations
Experimental genetic crosses in tsetse flies of the livestock pathogen Trypanosoma congolense savannah
First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis
From pole to pole, life-long research of sleep in extreme environments
Generation of a bloodstream form Trypanosoma brucei double glycosyltransferase null mutant competent in receptor-mediated endocytosis of transferrin
Genetic Diversity of Trypanosomes Infesting Cattle from Savannah District in North of Côte d'Ivoire Using Conserved Genomic Signatures: rRNA, ITS1 and gGAPDH
Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol
Guidelines for the treatment of human African trypanosomiasis
Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
How are Trypanosoma brucei receptors protected from host antibody-mediated attack?
Human African Trypanosomiasis (Sleeping Sickness)-Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention
Identification of transport systems involved in eflornithine delivery across the blood-brain barrier
Imaging Assays to Detect DNA Damage in Trypanosome Parasites Using γH2A
Improved serodiagnosis of Trypanosoma vivax infections in cattle reveals high infection rates in the livestock regions of Argentina
In vitro and in vivo antitrypanosomal activity of the fresh leaves of Ranunculus Multifidus Forsk and its major compound anemonin against Trypanosoma congolense field isolate
In vitro antitrypanosomal activity of synthesized nitrofurantoin-triazole hybrids against Trypanosoma species causing animal African trypanosomosis
Insights to Design New Drugs against Human African Trypanosomiasis Targeting Rhodesain using Covalent Docking, Molecular Dynamics Simulations, and MM-PBSA Calculations
Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF
Kagimminols A and B, Cembrene-Type Diterpenes from an Okeania sp. Marine Cyanobacterium
Knowledge, attitudes and practices towards yaws in endemic areas of Ghana, Cameroon and Côte d'Ivoire
Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy
Limited impact of vector control on the population genetic structure of Glossina fuscipes fuscipes from the sleeping sickness focus of Maro, Chad
Lipid Metabolism in Insect Vectors of Diseases
Modelled impact of Tiny Targets on the distribution and abundance of riverine tsetse
Modelling timelines to elimination of sleeping sickness in the Democratic Republic of Congo, accounting for possible cryptic human and animal transmission
Multifunctional Organometallic Compounds Active against Infective Trypanosomes: Ru(II) Ferrocenyl Derivatives with Two Different Bioactive Ligands
Novel 4-[4-(4-methylpiperazin-1-yl)phenyl]-6-arylpyrimidine derivatives and their antitrypanosomal activities against T.brucei
Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism
Pass the boron: benzoxaboroles as antiparasite drugs
Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei
Polyamine Metabolism for Drug Intervention in Trypanosomatids
Prevalence of dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis in Guinea
Privileged small molecules against neglected tropical diseases: A perspective from structure activity relationships
Prophylactic activity of orally administered dry-heat-sterilized Acremonium egyptiacum against Trypanosoma congolense-induced animal African trypanosomosis
Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids
Reproductive, productive and financial consequences of chronic Trypanosoma vivax infection in a dairy cattle herd in a region without a cyclic vector
Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity
Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study
State-of-the-art clinical update on African trypanosomiasis
Study on the underlying molecular mechanism of benzene-induced nervous system damage in mice based on tandem mass tag (TMT) proteomics
Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug
Synthesis and biological evaluation of orally active anti-Trypanosoma agents
Targeting Trypanothione Metabolism in Trypanosomatids
The activities of suaveolol and other compounds from Hyptis suaveolens and Momordica charantia against the aetiological agents of African trypanosomiasis, leishmaniasis and malaria
The comprehensive epidemiological status of human African trypanosomiasis in Nigeria: meta-analysis and systematic review of the full story (1962-2022)
The current status of neglected tropical diseases in Japan: A scoping review
The elimination of human African trypanosomiasis: Monitoring progress towards the 2021-2030 WHO road map targets
The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis
The internal transcribed spacer 1 sequence polymorphism brings updates to tsetse species distribution in the northern Cameroon: Importance in planning efficient vector control
The role of tryptophan derivatives as anti-kinetoplastid agents
The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana
To Explore Potential Inhibitors Against Various Enzymatic Targets of Human African Trypanosomiasis
Toll-like receptor 9 signaling is associated with immune responses to Trypanosoma brucei infection
Tractable Quinolone Hydrazides Exhibiting Sub-Micromolar and Broad Spectrum Antitrypanosomal Activities
Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology
Trypanocide usage in the cattle belt of southwestern Uganda
Trypanosoma brucei gambiense group 2 experimental in vivo life cycle: from procyclic to bloodstream form
Trypanosoma vivax in and outside cattle blood: Parasitological, molecular, and serological detection, reservoir tissues, histopathological lesions, and vertical transmission evaluation
Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case
Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei
Updating the northern tsetse distribution limit in Chad in the context of global change
Using Passive Surveillance to Maintain Elimination as a Public Health Problem for Neglected Tropical Diseases: A Model-Based Exploration
Virulence and pathogenicity of three Trypanosoma brucei rhodesiense stabilates in a Swiss white mouse model
What is needed to achieve effective and sustainable control of African animal trypanosomosis?