New York, NY – Metastatic disease, which occurs when cancer spreads from its original site to other areas of the body, is responsible for the majority of cancer-related deaths. While researchers understand how cancer cells escape the primary site to seed new tumors, it’s not well understood why some of these wayward cancer cells spawn new tumors— sometimes decades later—while others do not.
Now, a research team at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) has discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body. The findings were published today in the journal Cell.
“Preventing or curing metastases is the most critical challenge in cancer,” said study leader Julio Aguirre-Ghiso, Ph.D., director of MECCC’s Cancer Dormancy Institute. “We think our findings have the potential to point to new therapies to prevent or treat metastatic disease.” The study’s co-first authors are Erica Dalla, Ph.D., a former student, and Michael Papanicolaou, Ph.D., a postdoctoral fellow in Dr. Aguirre-Ghiso’s lab.
The Role of Dormancy in Cancer
Cells that migrate from primary tumors and seed metastatic tumors are called disseminated cancer cells (DCCs). Some DCCs behave aggressively, immediately starting tumors in new tissue, while others remain in a state of suspended animation referred to as dormancy.
“It’s long been a mystery how some DCCs can remain in tissues for decades and never cause metastases, and we believe we’ve found the explanation,” said Dr. Aguirre-Ghiso, who is also professor of cell biology, of oncology, and of medicine and the Rose C. Falkenstein Chair in Cancer Research at Albert Einstein College of Medicine.
Breast cancer and many other types of cancer metastasize to the lungs. In research involving three mouse models of metastatic breast cancer, Dr. Aguirre-Ghiso and colleagues determined that when breast cancer DCCs spread to the lung’s air sacs (alveoli), they are kept in a dormant state by immune cells known as alveolar macrophages.
Insight into the Immune System
“Alveolar macrophages are the lung’s first responders, defending the organ against bacteria and dangerous substances like environmental pollutants,” said Dr. Aguirre-Ghiso. These specialized macrophages, he notes, appear early in embryonic development and reside within lung tissue for life.
“Our findings demonstrate a new role for these macrophages, in which they recognize DCCs and actively interact with them, and—by secreting a protein called TGF-β2—produce signals in the cancer cells that keep them in a dormant state,” Dr. Aguirre-Ghiso said. “Since every organ in the body has its own set of tissue-resident macrophages, they may function to keep DCCs in check in those organs as well. Our study has shown for the first time that these specialized macrophages function to actively induce dormancy in DCCs.”
Confirming the importance of alveolar macrophages in keeping DCCs dormant, Dr. Aguirre-Ghiso and his team found that depleting them in the mice significantly increased the number of activated DCCs and subsequent metastases in their lungs compared to mice with normal levels of the immune cells.
As DCCs become more aggressive, the researchers found, they become resistant to the pro-dormancy signals produced by alveolar macrophages. Ultimately, this evasion mechanism enables some DCCs to “wake up” from dormancy and reactivate to form metastases.
“Understanding how immune cells keep DCCs in check could lead to new anti-metastatic cell therapies among other strategies,” Dr. Aguirre-Ghiso said. For example, he noted, it may be possible to strengthen macrophage signaling so that DCCs never awaken from dormancy or find ways to prevent older DCCs from becoming resistant to dormancy signaling.
The study is titled, “Lung resident alveolar macrophages regulate the timing of breast cancer metastasis.” Additional authors from MECCC include: Nicole Barth Ph.D (also at University of Edinburgh, UK), Deisy Segura-Villalobos, Ph.D., Luis Valencia-Salazar, B.A., Dan Sun Ph.D., and David Entenberg, Ph.D. Other authors include: Matthew Park, Ph.D., and Miriam Merad, M.D., Ph.D., at Icahn School of Medicine at Mount Sinai, New York, NY, Rui Hou, Ph.D., and Alistair R. R. Forrest, Ph.D., at The University of Western Australia, Nedlands, Australia, and Maria Casanova-Acebes, Ph.D., at Spanish National Cancer Centre, Madrid, Spain.
About Montefiore Einstein Comprehensive Cancer Center
Montefiore Einstein Comprehensive Cancer Center (MECCC) is a National Cancer Institute (NCI)-designated comprehensive cancer center and a national leader in cancer research and care located in the racially and ethnically diverse borough of the Bronx, N.Y. MECCC combines the exceptional science of Albert Einstein College of Medicine with the multidisciplinary and team-based approach to cancer clinical care at Montefiore Health System. Founded in 1971 and a NCI-designated cancer center since 1972, MECCC is redefining excellence in cancer research, clinical care, education and training, and community outreach and engagement. Its mission is to reduce the burden of cancer for all, especially people from historically underrepresented groups.
Contact
Elaine Iandoli
Albert Einstein College of Medicine
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Office: 347-852-8679