RNA regulatory mechanisms implicated in human diseases both rare and common

The clinical and
mechanistic aspects of many rare diseases; for example, Cockayne
syndrome and related DNA repair/transcription defective disorders such
as the Xeroderma pigmentosum and trichothiodystrophy will be explored,
as will other rare disease relationships as noted above. Our goal is to
develop new multidisciplinary collaborations, interactions and
relationships that can lead to a greater understanding of the
pathophysiological mechanisms involved in these disorders and to
conceive new therapeutic strategies for their treatment.