Dysmorphism and radiological signs can be good diagnostic handles for a number of inborn errors of metabolism (IEM). The course will focus on these clinical aspects of IEMs. The venue is Manchester, U.K., home of the Willink Biochemical Genetics Unit and one of the leading centres for clinical dysmorphology. We have assembled world experts in the field for the course. The topics covered will be of interest to clinicians who deal with rare disorders or have an interest in clinical genetics, IEMs or Paediatrics. It is expected that participants will have some background knowledge of the field although extensive experience is not required. Participants are strongly recommended to bring interesting, unusual or unsolved cases.