Weismann Netter Stuhl syndrome

December 31, 2014

Overview

Weismann-Netter-Stuhl Syndrome: A very rare inherited disorder characterized by bone development abnormalities.

Symptoms

Short stature Mental retardation Concentration difficulties Learning difficulties Bowed legs

Causes

Physiologic –At birth, normal alignment is 1–15° of varus –Remodeling of bone resulting in neutral alignment occurs by 2 years of age Tibia vara (Blount disease) –Osteochondrosis of the medial tibial physis, combined with early walking and obesity, leads to compression across the physis that prevents normal growth –Increased incidence in males, blacks, and obese children –Infantile tibia vara (1–3 years old) is the most common form, is usually bilateral –Juvenile (4–1) and adolescent (>11) forms also exist, differing mainly in age at onset, remaining growth, and amount of compressive forces across posterior tibial medial physis o Rickets –Growing bone is inadequately mineralized due to vitamin D deficiency (nutritional rickets) or a defect in mineral metabolism (X-linked hypophosphatemia) Skeletal dysplasias –Achondroplasia –Enchondromatosis –Metaphyseal dysplasia Trauma –Injury to proximal tibia physis may lead to growth arrest of physeal bar

Diagnosis

The phrase "signs of Weismann-Netter-Stuhl Syndrome" should, strictly speaking, refer only to those signs and symptoms of Weismann-Netter-Stuhl Syndrome that are not readily apparent to the patient. The word "symptoms of Weismann-Netter-Stuhl Syndrome" is the more general meaning; see symptoms of Weismann-Netter-Stuhl Syndrome. The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Weismann-Netter-Stuhl Syndrome. This medical information about signs and symptoms for Weismann-Netter-Stuhl Syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of Weismann-Netter-Stuhl Syndrome signs or Weismann-Netter-Stuhl Syndrome symptoms. Furthermore, signs and symptoms of Weismann-Netter-Stuhl Syndrome may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Weismann-Netter-Stuhl Syndrome symptoms.