Tylosis
Overview
A condition characterized by thickening of the skin on the palms of the hands and soles of the feet. The condition is associated with a risk of developing esophageal cancer which increases with age.
Symptoms
* Thickening of skin on soles * Thickening of skin on palms
Causes
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Tylosis may be found in: * Hidden causes of Tylosis
Diagnosis
In cases of diffuse thickening of the skin, a thyroid profile with T 3 , T 4 , and TSH should be done. This should also identify hypothyroidism. A positive ANA test with a speckled pattern will help identify scleroderma, but a skin biopsy should also be done. An antisclerodermal antibody titer is also useful if available. Esophageal motility studies will be helpful in early diagnosis. A skin biopsy will help identify many of the other conditions mentioned above. Urine for porphyrins will help identify porphyria.