Spastic ataxia Charlevoix-Saguenay type
Overview
Spastic ataxia, Charlevoix-Saguenay type: A rare disorder characterized mainly by spasticity of the legs, uncoordinated leg movements and eye anomalies.
Symptoms
Abnormal walk Involuntary rapid eye movements Dysarthria Limb spasticity Lower leg muscle wasting
Causes
The pathophysiology of this syndrome is most likely related to an abnormality of normal vasodilator function within the coronary arteries and/or a hypersensitivity of the coronary arteries to normal mediators of vasoconstriction. The underlying cause of these abnormalities of vasomotor function is unknown. Subclinical or clinical atherosclerosis is almost ubiquitous in patients with variant angina, although the reason this subgroup of patients should present with focal coronary artery vasospasm remains unclear. Smoking, hyperinsulinemia, and insulin resistance are probable risk factors for variant angina