Nesidioblastosis of pancreas

Overview

Nesidioblastosis of pancreas: A rare genetic disorder where abnormal islets of Langerhans cells in the pancreas produce excess insulin which causes very low blood sugar levels. Untreated low blood sugar can cause permanent brain damage.

Symptoms

The list of signs and symptoms mentioned in various sources for Nesidioblastosis of pancreas includes the 5 symptoms listed below: * Severe neonatal hypoglycemia * High blood insulin level * Fainting * Low blood glucose * Lack of ketone bodies in urine

Causes

Fainting

Diagnosis

Home medical testing related to Nesidioblastosis of pancreas: * High Cholesterol: Home Testing: o Home Cholesterol Tests o Home Triglycerides Tests o Home Blood Pressure Tests * High Blood Pressure: Home Testing o Home Blood Pressure Monitors o Home Heart Tests * Heart Health: Home Testing: o Heart Rate Monitors o Irregular Heartbeat Detection o Heart Electrocardiogram (ECG) * Thyroid: Home Testing: o Home Thyroid Function Tests o Home TSH Tests o Home Adrenal Function Tests * Diet & Weight Loss: Home Testing: o Home Weight Testing o Home Body Fat Testing (BMI) o Home Body Fat Monitoring o Home Fitness Testing * Diabetes: Related Home Testing: o Home Diabetes Tests o Home Blood Glucose Tests o Home Urine Glucose Tests o Home Urine Ketone Tests o Home Diabetes HbA1c Tests o Home Microalbumin Tests (Kidney) o Home Urine Protein Tests (Kidney) o Home Kidney Tests o Home Eye Tests

Treatment

* Glucose therapy (therapy goal is glucose >100 mg/dL) –Alert patients may be repleted with oral glucose (e.g., juice, glucose tablets) or IV D50 –Patients with altered consciousness require IV D50 solution –In children, use bolus of 25% dextrose –Frequently recheck blood glucose , Glucagon may be used to increase glucose release from the liver if unable to obtain IV access and the patient cannot tolerate oral glucose; less effective in alcoholic and malnourished patients , Octreotide may be used in cases of sulfonylurea-induced hypoglycemia to inhibit insulin release , Thiamine must be given with glucose in any suspected case of alcohol abuse or nutritional deficiency to avoid Wernicke's encephalopathy , Hydrocortisone should be administered if blood glucose remains persistently low to rule out adrenal insufficiency