Myhre School syndrome
Overview
A very rare inherited disorder characterized by retarded growth, mental retardation, bone abnormalities and distinctive facial featuresMental retardation, growth deficiency, midfacial hypoplasia, hearing loss, generalized muscular hypertrophy, joint limitation, and skeletal abnormalities are the cardinal features of this syndrome
Symptoms
The list of signs and symptoms mentioned in various sources for Myhre Syndrome includes the 20 symptoms listed below: * Prenatal growth deficiency * Postnatal growth deficiency * Mental retardation * Deafness * Unusual facies * Underdeveloped upper jaw bone * Prognathism * Short eyelids * Small mouth * Enlarged muscles * Decreased joint mobility * Undescended testes * Heart anomalies * Thickened cranium * Broad ribs * Large vertebrae * Flattened vertebrae * Underdeveloped iliac wings * Short long bones * Joint stiffness
Causes
1. Normalvariations 1. Constitutionaldelay of growth and maturation 2. Genetic (familial) short stature 2. Disorders primarily affecting weight 1. Intrauterinegrowth disturbance 2. Undernutrition 3. Excessive calorie wasting (vomiting,diarrhea, polyuria) 4. Chronic disease 5. Psychologic disorders 1. Psychosocialdeprivation 2. Anorexia nervosa 3. Depression 4. Psychosis 3. Disorders primarily affecting skeletalgrowth (height) 1. Chromosomal abnormalities 2. Dysmorphic syndromes 3. Bone and cartilage disorders (osteochondrodysplasias) 4. Endocrine disorders 1. Hypothyroidism 2. Glucocorticoid excess 3. Growth hormone deficiency/insensitivity