Keratosis palmoplantar periodontopathy
Overview
A very rare inherited condition characterized by dry scaly patches on the skin of the palms and soles, gum and teeth problems and frequent skin infections .
Symptoms
* Dry scaly skin on palms * Dry scaly skin on soles * Premature loss of primary teeth usually by 5 years of age * Premature loss of permanent teeth usually by 17 years of age * Inflammation of gums * Degeneration of tooth support structures * Skin infection usually pus-producing * Nail abnormalities * Excessive sweating
Diagnosis
In cases of diffuse thickening of the skin, a thyroid profile with T 3 , T 4 , and TSH should be done. This should also identify hypothyroidism. A positive ANA test with a speckled pattern will help identify scleroderma, but a skin biopsy should also be done. An antisclerodermal antibody titer is also useful if available. Esophageal motility studies will be helpful in early diagnosis. A skin biopsy will help identify many of the other conditions mentioned above. Urine for porphyrins will help identify porphyria.