Nerve disorder involving the sacral plexus which is a group of nerves that start in the lower tailbone area and supply the lower legs. The sciatic nerve is involved in the group of nerves. The nerve damage can occur through trauma disease or tumors.
A very rare syndrome characterized by the abnormal development of the tailbone.
Sacrococcygeal Teratoma / SCT is a tumor made up of tissues from the three primary layers of cells defined in embryos, or germ layers. Sacrococcygeal Teratoma / SCT appear in the lower back and buttocks. The tumors can grow at an unpredictable rate to very large dimensions and present both inside and outside the fetal pelvis. Some tumors are diagnosed in utero, others at birth.
Though a rare condition (1 in 35,000-40,000 births), Sacrococcygeal Teratoma / SCT is one of the most common tumors in newborns. Females are four times more likely to be affected than males. Malignancies are more frequent in males.
Source: Fetal Care Center of Cincinnati
Saethre-Chotzen syndrome is an inherited disorder that affects one in every 50,000 individuals. The syndrome is characterized by early and uneven fusion of the bones that make the skull (cranium). This affects the shape of the head and face, which may cause the two sides to appear unequal. The eyelids are droopy; the eyes widely spaced. The disorder is also associated with minor birth defects of the hands and feet. In addition, some individuals have mild mental retardation. Some individuals with Saethre-Chotzen syndrome may require some medical or surgical intervention.
A very rare syndrome characterized by kidney abnormalities and an abnormal calf bone or forearm bone (ulna). Only a few cases of the syndrome have been reported.
A rare genetic condition characterized by head and digital anomalies as well as other abnormalities.
A very rare syndrome characterized by kidney disease.
There are different types of treatment for patients with salivary gland cancer. Different types of treatment are available for patients with salivary gland cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Before starting treatment, patients may want to think about taking part in a clinical trial. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site. Choosing the most appropriate cancer treatment is a decision that ideally involves the patient, family, and health care team. Patients with salivary gland cancer should have their treatment planned by a team of doctors who are experts in treating head and neck cancer.
Salla disease (also called sialic acid storage disease or Finnish type sialuria) is an autosomal recessive lysosomal storage disease characterized by early physical impairment and mental retardation. First described in 1979, Salla disease is named after Salla, a municipality in Finnish Lapland. Salla disease is one of 40 Finnish heritage diseases and affects approximately 130 individuals, mainly from Finland and Sweden.
A rare inherited syndrome characterized mainly by hand and foot abnormalities.
Sammartino Decreccio syndrome: Another name for Corneal dystrophy - ichthyosis - microcephaly - mental retardation (or close medical condition association). Corneal dystrophy - ichthyosis - microcephaly - mental retardation: A very rare syndrome characterized by vision loss, scaly skin, small head and mental retardation.
A very rare syndrome characterized mainly by premature fusion of skull bones, small skull, elbow fusion and thumb abnormalities. There is also an abnormal sack of fluid between the brain and the skull.
A very rare syndrome characterized by small ears, abnormal chest wall and facial, lip and palate clefts.
A very rare syndrome characterized by overlapping fingers, abnormally placed urethral opening in males, protruding eyes and Robin association (small jaw and downward displaced tongue).
A rare disorder characterized by an underdeveloped kneecap and other skeletal abnormalities.
Sandhoff disease, is a lysosomal genetic, lipid storage disorder caused by the inherited deficiency to create functional beta-hexosaminidases A and B. These catabolic enzymes are needed to degrade the neuronal membrane components, ganglioside GM2, its derivative GA2, the glycolipid globoside in visceral tissues, and some oligosaccharides. Accumulation of these metabolites leads to a progressive destruction of the central nervous system and eventually to death. The rare autosomal recessive neurodegenerative disorder is clinically almost indistinguishable from Tay-Sachs disease, another genetic disorder that disrupts beta-hexosaminidases A and S. There are three subsets of Sandhoff disease based on when first symptoms appear: classic infantile, juvenile and adult late onset.
Sandifer syndrome (or Sandifer's syndrome) is a paediatric medical disorder, characterised by gastrointestinal symptoms and associated neurological features There is a significant correlation between the syndrome and gastroesophageal reflux disease (GERD); however, it is estimated to occur in less than 1% of children with reflux.[
Mucopolysaccharidosis type III is a progressive disorder that mainly affects the brain and spinal cord (central nervous system).
People with MPS III generally do not display any features of the condition at birth, but they begin to show signs and symptoms of the disorder during early childhood. Affected children often initially have delayed speech and behavior problems. They may become restless, destructive, anxious, or aggressive. Sleep disturbances are also very common in children with MPS III. This condition causes progressive intellectual disability and the loss of previously acquired skills (developmental regression). In later stages of the disorder, people with MPS III may develop seizures and movement disorders.
The physical features of MPS III are less pronounced than those of other types of mucopolysaccharidosis. Individuals with MPS III typically have mildly "coarse" facial features, a large head (macrocephaly), a slightly enlarged liver (mild hepatomegaly), and a soft out-pouching around the belly-button (umbilical hernia) or lower abdomen (inguinal hernia). Some people with MPS III have short stature, joint stiffness, or mild dysostosis multiplex, which refers to multiple skeletal abnormalities seen on x-ray. Affected individuals often develop chronic diarrhea and recurrent upper respiratory and ear infections. People with MPS III may also experience hearing loss and vision problems.
MPS III is divided into types IIIA, IIIB, IIIC, and IIID, which are distinguished by their genetic cause. The different types of MPS III have similar signs and symptoms, although the features of MPS IIIA typically appear earlier in life and progress more rapidly. People with MPS III usually live into adolescence or early adulthood.
Santos-Mateus-Leal syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Santos-Mateus-Leal syndrome, or a subtype of Santos-Mateus-Leal syndrome, affects less than 200,000 people in the US population.
SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. Synovitis means inflammation of the joint lining (synovium). Typically, this is manifests as warmth, tenderness, pain, swelling, and stiffness of involved joints (arthritis). Acne is a skin condition featuring tiny areas of inflammation with pus formation at the hair follicles. Acne occurs most commonly on the face and upper back. Pustulosis is a very inflammatory skin condition resulting in large fluid-filled blister-like areas (pustules), typically on the palms of the hands and/or the soles of the feet. The skin of these areas peels and flakes (exfoliates). Hyperostosis means abnormal excessive growth of bone. The hyperostosis of the SAPHO syndrome frequently is located at the points of the bone where tendons attach. Osteitis means inflammation of the bone. Patients with SAPHO syndrome can develop inflammation of the sacroiliac joints (sacroiliitis) as well as inflammation of the spine (spondylitis) which leads to stiffness and pain of the neck and back.
Sarcoidosis is an inflammatory disease characterized by the development and growth of tiny lumps of cells called granulomas. If these tiny granulomas grow and clump together in an organ, they can affect how the organ works, leading to the symptoms of sarcoidosis. The granulomas can be found in almost any part of the body, but occur more commonly in the lungs, lymph nodes, eyes, skin, and liver. Although no one is sure what causes sarcoidosis, it is thought by most scientists to be a disorder of the immune system responding to an unknown substance, most likely something inhaled from the air. The course of the disease varies from person to person, but most people do very well with little or only modest treatment. It often goes away on its own, but in some people symptoms of sarcoidosis may last a lifetime. For those who need treatment, anti-inflammatory medications and immunosuppressants can help. In half of cases, sarcoidosis goes away on its own. In a few cases, however, sarcoidosis may last for years and may cause organ damage.
A rare disease involving inflammation of the lungs which leads to the development of nodules, fibrosis and scarring of lung tissue.
An aggressive form of cancer that arises from embryonic muscle cells. The tumor resembles a bunch of grapes and tends to occur in the genitourinary tract. Common locations are the cervix, vagina and bladder and very rare cases can occur in the bile duct or the soft tissues of the head and neck. It occurs most often in female infants and young children. Symptoms will vary depending on the exact location of the tumor
A rare metabolic disorder where the blood level of sarcosine in increased due to a deficiency of sarcosine dehydrogenase which is needed to break it down. It is considered a harmless condition with no noticeable symptoms.
Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus (SARS-CoV).[1] There has been one near pandemic to date, between November 2002 and July 2003, with 8,096 known infected cases and 774 deaths (a case-fatality rate of 9.6%) worldwide being listed in the World Health Organization's (WHO) 21 April 2004 concluding report.[2] Within a matter of weeks in early 2003, SARS spread from the Guangdong province of China to rapidly infect individuals in some 37 countries around the world[3]
A very rare syndrome characterized by alopecia, diarrhea, skeletal abnormalities and painful leg cramps caused by physical exercise or emotional stress.
A dominantly inherited disorder involving muscle wasting and weakness that occurs mainly in the shoulder and lower leg muscles. It results from a defect in the MYH7 gene on chromosome 14q12.
An inherited disorder involving muscle wasting and weakness in the shoulder and lower leg. The legs are often affected first.
A rare syndrome characterized mainly by skeletal abnormalities, loose skin, premature fusion of skull bones, ambiguous genitalia, psychomotor retardation and facial abnormalities.
A very rare syndrome characterized mainly by deafness, cataracts and a deficiency of sex hormone production.