Fraser like syndrome
Overview
Fraser-like syndrome: A very rare syndrome characterized by fused eyelids, airway anomalies, cysts in the ovaries and finger and toe abnormalities.
Symptoms
Fused eyelids Craniofacial anomalies Ovarian cyst Narrowed subglottis Overlapping 2nd and 3rd fingers
Causes
Follicular cysts are generally very small and arise from follicles that overdistend. When such cysts persist into menopause, they secrete excessive amounts of estrogen in response to the hypersecretion of follicle-stimulating hormone and luteinizing hormone that normally occurs during menopause. (See Follicular cyst.) Granulosa-lutein cysts, which occur within the corpus luteum, are functional, nonneoplastic enlargements of the ovaries caused by excessive accumulation of blood during the hemorrhagic phase of the menstrual cycle. Theca-lutein cysts are commonly bilateral and filled with clear, straw-colored fluid; they’re often associated with hydatidiform mole, choriocarcinoma, or hormone therapy (with human chorionic gonadotropin [hCG] or clomiphene citrate). Polycystic ovarian disease is part of the Stein-Leventhal syndrome and stems from endocrine abnormalities.