Letterer-Siwe disease

Overview

Letterer-Siwe disease is a type of histiocytosis[1] (a condition where histiocytes proliferate in the body.) It is sometimes classified as a form of Langerhans cell histiocytosis,[2] or as a form of histiocytosis X.[3] It is most commonly seen in children less than two years old. It is named for Erich Letterer and Sture Siwe

Symptoms

• Fatigue
• Anorexia
• Irritability
• Wasting
• Chronic middle ear inflammation

Prognosis

Untreated, the disease is fatal. The five-year survival rate with treatment is fifty percent.