Small non-cleaved cell lymphoma
Overview
Alternative Names: Burkitt lymphoma, B-cell lymphoma; High-grade B-cell lymphoma; Small non-cleaved cell lymphoma Burkitt lymphoma is a very fast growing form of non-Hodgkin's lymphoma.
Symptoms
Burkitt lymphoma may first be noticed as a swelling of the lymph nodes (glands) in the neck, groin, below the jaw, or under the arm. These swollen lymph nodes are often painless, but can grow very rapidly. In the more common types seen in the United States, the cancer usually starts in the belly area (abdomen). The disease can also start in the ovaries, testes, brain, and spinal fluid. Symptoms include: * Nodes that grow together to form a lump * Non-tender nodes * Rapid growth of the lymph nodes * Unexplained swollen lymph nodes
Causes
This type of tumor was first discovered in children in certain parts of Africa, but it also occurs in the United States. The African type of Burkitt lymphoma is closely associated with the Epstein-Barr virus (EBV), the main cause of infectious mononucleosis. The North American form of Burkitt lymphoma is not linked to EBV. The majority of Burkitt lymphoma cases are seen in males.
Diagnosis
* Bone marrow biopsy * Chest x-ray * CT scan of the chest, abdomen, and pelvis * Examination of the spinal fluid * Lymph node biopsy * PET or gallium scan
Prognosis
More than half of those with Burkitt lymphoma can be cured with intensive chemotherapy. The cure rate may be lower if the cancer spreads to the bone marrow or spinal fluid.
Treatment
Chemotherapy is used to treat this type of cancer. Commonly used medicines include prednisone, cyclophosphamide, vincristine, cytarabine, doxorubicin, methotrexate, and others.
Resources
Call your health care provider if you have symptoms of Burkitt lymphoma.