Growth mental deficiency syndrome of Myhre
Overview
Myhre syndrome is an extremely rare inherited disorder characterized by mental retardation, short stature, unusual facial features, and various bone (skeletal) abnormalities
Symptoms
Characteristic facial features may include abnormally narrow skin folds (palpebral fissures) between the upper and lower eyelids (blepharophimosis), underdevelopment of the upper jaw bone (maxillary hypoplasia), and an unusually prominent jaw (prognathism).
Causes
Normalvariations Constitutionaldelay of growth and maturation Genetic (familial) short stature Disorders primarily affecting weight Intrauterinegrowth disturbance Undernutrition Excessive calorie wasting (vomiting,diarrhea, polyuria) Chronic disease Psychologic disorders Psychosocialdeprivation Anorexia nervosa Depression Psychosis Disorders primarily affecting skeletalgrowth (height) Chromosomal abnormalities Dysmorphic syndromes Bone and cartilage disorders (osteochondrodysplasias) Endocrine disorders Hypothyroidism Glucocorticoid excess Growth hormone deficiency/insensitivity