Anonychia congenita

Synonyms

3

Overview

Anonychia congenita is an extremely rare nail disorder characterized by the complete absence (anonychia) or abnormally developed fingernails and toenails. Affected individuals usually do not have hair, teeth, or bone abnormalities. Less than 20 individuals with anonychia congenita have been identified.

Symptoms

Signs and symptoms are variable, even among affected members of the same family.

• Absent fingernails
• Absent toenails

Causes

This condition is thought to be caused by mutations in the RSPO4 gene and inherited in an autosomal recessive fashion.

Treatment

There is limited information regarding anonychia congenita because it is very rare. There is not any information about treatment for this condition.

Resources

• NIH