Tremor hereditary essential- 1
Overview
Tremor hereditary essential, 1: An inherited movement disorder involving tremors which occurs mainly in the arms but other parts of the body are often involved. Any kind of stress on the body such as hunger and tiredness can aggravate the condition.
Symptoms
The list of signs and symptoms mentioned in various sources for Tremor hereditary essential, 1 includes the 5 symptoms listed below: Tremors Dysarthria Stiff walk Rigid walk Facial tremor Note that Tremor hereditary essential, 1 symptoms usually refers to various symptoms known to a patient, but the phrase Tremor hereditary essential, 1 signs may refer to those signs only noticable by a doctor.
Causes
The underlying etiology is not clear but many cases seem to be familial.It has been estimated that approximately one-half of the cases are due to a genetic mutation and the pattern of inheritance is most consistent with autosomal dominant transmission. As of yet, no genes have been identified but genetic linkage has been established with several chromosomal regions. A number of environmental factors, including toxins, are also under active investigation and these may play a role in disease etiology.In terms of pathophysiology, clinical, physiological and imaging studies point to an involvement of the cerebellum and/or cerebellothalamocortical circuits.Recent postmortem studies have demonstrated the presence of degenerative changes in the ET brain, with these changes including Purkinje cell axonal swellings and Purkinje cell loss in the majority of cases and brainstem Lewy bodies in the remainder. These studies suggest that the disease is both heterogeneous and degenerative. In other words, ET might be a family of degenerative diseases rather than a single disease.
Diagnosis
Usually the diagnosis is established on clinical grounds. Tremors can start at any age, from birth through advanced ages (senile tremor). Any voluntary muscle in the body may be affected, although the tremor is most commonly seen in the hands and arms and slightly less commonly in the neck (causing the patient's head to shake), tongue, and legs. A resting tremor of the hands is sometimes present.
Prognosis
The 'prognosis' of Tremor hereditary essential, 1 usually refers to the likely outcome of Tremor hereditary essential, 1. The prognosis of Tremor hereditary essential, 1 may include the duration of Tremor hereditary essential, 1, chances of complications of Tremor hereditary essential, 1, probable outcomes, prospects for recovery, recovery period for Tremor hereditary essential, 1, survival rates, death rates, and other outcome possibilities in the overall prognosis of Tremor hereditary essential, 1. Naturally, such forecast issues are by their nature unpredictable.