Miller Fisher syndrome
Overview
A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves.
Symptoms
The list of signs and symptoms mentioned in various sources for Miller Fisher Syndrome includes the 5 symptoms listed below: * Ataxia * Ophthalmoplegia * Areflexia (absence of reflexes) * Generalized muscle weakness * Respiratory failure Note that Miller Fisher Syndrome symptoms usually refers to various symptoms known to a patient, but the phrase Miller Fisher Syndrome signs may refer to those signs only noticable by a doctor.
Causes
Other Possible Causes of these Symptoms * Areflexia (absence of reflexes) * Ataxia * Generalized muscle weakness * Ophthalmoplegia * Respiratory failure
Diagnosis
The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.