Hyper-reninism
Overview
An autonomous, excessive renin-producing tumor results secondary hyperaldosteronism with the subsequent hypertension
Symptoms
* Volume dependency: increased absorption of sodium and water as a mineralocorticoid effect of high concentrations of cortisol. * Increased peripheric resistance: stimulated RAS activity at high concentrations of glucocorticoids with a subsequent overproduction of ATII. * Direct vasoconstrictor effect of aldosterone. * Effect of aldosterone for the hypothalamic cardiovascular regulator center.
Diagnosis
* Pharmacological: o K-supplementation o K-sparing diuretics (amiloride, triamterene, spironolactone) o Ca-antagonists o ACE-inhibitors * Non-pharmacological: o Surgical treatment: removal of the primary tumor