Dysfibrinogenemia- familial
Overview
Dysfibrinogenemia, familial is a type of familial medication condition that is not common. It is associated with an abnormal fibrinogen. Dysfibrinogenemia, familial involves several types and subtypes including Detroit, Wiesbaden, and Amsterdam dysfibrinogenemia.
Symptoms
* Abnormal bleeding * Blood clots * Prolonged blood clotting time * Asymptomatic
Causes
Because Dysfibrinogenemia, familial is a hereditary disease, this is passed on from the parents to their children. The disease is typically inherited in a codominant or autosomal dominant style.
Diagnosis
Lab testing algorithm is present to diagnose dysfibrinogenemia, familial. Testing starts with screening tests that are nonspecific but very sensitive, and then goes on to several other tests that are more specific than the previous ones. The testing algorithm is normally used in patients whose bleeding issues have not been explained by acquired entities.
Treatment
Transfusion of Cryoprecipitate or fresh frozen plasma would depend on the extent of bleeding problem. Patients who are experiencing recurring thrombotic episodes may need prolonged treatment with an anticoagulation called Coumadin. To address recurrent miscarriages, doctors may administer prophylactic cryoprecipitate.