LOS ANGELES, Calif. — Kairos Pharma, Ltd., a clinical stage biopharmaceutical company developing cancer therapeutics designed to reverse cancer drug resistance and immune suppression, announces the dosing of its first patient in its Phase 2 trial testing a combination therapy for its lead therapeutic candidate ENV105 in combination with apalutamide for the treatment of castrate resistant prostate cancer (CRPC).
Kairos Pharma CEO John Yu stated, “Many cancer therapeutics run up against the problem of resistance as the cancer circumvents their mechanism of action, thereby making the therapeutic ineffective, or sometimes less effective over time. Whether it be in prostate cancer or lung cancer, Kairos’s ENV105 is designed to reverse this resistance. This randomized multi-institutional Phase 2 trial will compare the efficacy of the combination of ENV105 and apalutamide with apalutamide alone in treating castrate-resistant prostate cancer.”
Prostate cancer patients that develop resistance to androgen signaling inhibitors are often given chemotherapy with androgen signaling inhibition combination. While effective initially, the side effects from such a combination can be intolerable. Based on previous open-label clinical studies demonstrating the conversion of 44% of CRPC patients to castrate sensitivity with ENV105, the primary objective of this randomized trial is to evaluate the efficacy of the novel combination therapy. The multi-site trial aims to enroll 100 patients who have already developed resistance to androgen receptor signaling inhibitors.
Dr. Neil Bhowmick, Chief Scientific Officer at Kairos Pharma, added, “Studying the second indication for ENV105, next to lung cancer, this Phase 2 trial is the product of extensive work to best understand its mechanism of action and develop essential clinical experience in prostate cancer patients.”
About Kairos Pharma
Based in Los Angeles, California, Kairos Pharma, Ltd. is a clinical-stage biopharmaceutical company focused on developing a diversified pipeline of cutting-edge oncology therapeutics that reverse the inhibitory effects of cancer on the immune system. The Company is advancing its portfolio of innovative drug candidates designed to reverse resistance and immune suppression from cancer.
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