Agyria-pachygyria type 1

Overview

Agyria-pachygyria type 1 is an abnormal brain development where the brain fails to develop normally during the fetal stage.

Symptoms

• Small brain
• Mental retardation
• Smooth brain
• Spasticity
• Seizure
• Broad shallow brain gyre

Diagnosis

Different imaging modalities are commonly used for diagnosis:

• Computed tomography (CT) is a lower-resolution imaging modality available, however, cerebral cortex malformations are more easily visualized in vivo
• classified using high-resolution magnetic resonance imaging (MRI) equipment

Treatment

Because pachygyria is a structural defect no treatments are currently available other than symptomatic treatments, especially for associated seizures. Another common treatment is a gastrostomy (insertion of a feeding tube) to reduce possible poor nutrition and repeated aspiration pneumonia.