Charcot-Marie-Tooth disease- Type 1B
Overview
CMT is an inherited neurological disease characterized by the gradual degeneration of nerves which starts in the hands and feet and results in progressive numbness, muscle weakness and loss of function. Type 1B is inherited as an autosomal dominant pattern and involves a defect in the MPZ gene on chromosome 1. The severity of the condition is variable depending on the age of onset with severe infantile cases resulting in the inability to walk at an early age.
Symptoms
* Slow running during childhood * High foot arches * Hammer toes * Foot weakness * Hand weakness * Balance problems * Foot drop * Wasted hand muscles * Wasted foot muscles * Hand pain * Foot pain * Wasted calf muscles * Pain in extremities * Loss of sensation in extremities * Incoordination * Claw hands * Reduced nerve conduction speed * Reduced deep tendon reflexes
Diagnosis
This medical information about signs and symptoms for Charcot-Marie-Tooth disease, Type 1B has been gathered from various sources, may not be fully accurate, and may not be the full list of Charcot-Marie-Tooth disease, Type 1B signs or Charcot-Marie-Tooth disease, Type 1B symptoms. Furthermore, signs and symptoms of Charcot-Marie-Tooth disease, Type 1B may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Charcot-Marie-Tooth disease, Type 1B symptoms.