We will discuss insights gathered from the study of model
genetic organisms and human cells on the intersection between RecQ
helicases and the responses to DNA damage, examining (1) the
biochemistry of RecQ helicases, (2) RecQ`s roles in DNA replication and
DNA repair, (3) RecQ helicases and intra-S phase checkpoint signaling,
(4) mouse models of RecQ helicase deficiency, (5) the function of RecQ
helicases at specialized DNA substrates such as telomeres, and (6)
RecQ?s effects on cancer and aging. We will also discuss the
advancement of potential therapies to prevent the genomic instability
of Bloom?s syndrome.
