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– To determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of
sorafenib in combination with FOLFOX4 (oxaliplatin/leucovorin/5-fluorouracil) as
first-line treatment for advanced gastric cancer
– The design of the study incorporated a standard 3 + 3 dose escalation procedure to
guide elevation of the sorafenib dosage to the next level