Oxalosis
Overview
A rare inherited metabolic disorder where excess oxalic acid forms crystals which make up urinary stones. In type I primary hyperoxaluria there is a deficiency of peroxisomal alanine-glyoxalate aminotransferase and type II involves a deficiency of the enzyme glyoxylate reductase/hydroxypyruvate reductase.
Symptoms
* Kidney stones * Nephrocalcinosis * Chronic renal insufficiency * Lack of urine production * Nausea
Causes
* Ethylene glycol * Hyperoxaluria, primary type 1 * Cellulose sodium phosphate * Hyperoxaluria, primary type 2 * Malabsorption syndrome
Treatment
Vitamin B6 - possibly used for related vitamin B6 deficiency